Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTTP | P55157 | 13/20 | 0.42 |
| ▸ | APOB | P04114 | 12/20 | 0.42 |
| ▸ | FPR2 | P25090 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6966432 | 0.87 | APOB (0.40) | MTTPAPOBFPR2 | |
| SCHEMBL6965865 | 0.81 | APOB (0.41) | MTTPAPOBGAAMAPT | |
| SCHEMBL6962760 | 0.80 | APOB (0.44) | MTTPAPOBGAA | |
| SCHEMBL6974662 | 0.80 | EPHX2 (0.45) | MTTPAPOB | |
| SCHEMBL6970162 | 0.79 | NAMPT (0.47) | MTTPAPOB | |
| SCHEMBL6966580 | 0.78 | SCN9A (0.43) | MTTPAPOB | |
| SCHEMBL6962034 | 0.77 | APOB (0.44) | MTTPAPOBGAAMAPT | |
| SCHEMBL6974835 | 0.77 | ABCB1 (0.48) | MTTPAPOBMAPT | |
| SCHEMBL6966377 | 0.77 | APOB (0.44) | MTTPAPOB | |
| SCHEMBL6964486 | 0.76 | PLAU (0.46) | MTTPAPOBGAAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0832069-B1 | BIPHENYL-2-CARBOXYLIC ACID-TETRAHYDRO-ISOQUINOLIN-6-YL AMIDE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS INHIBITORS OF MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN AND/OR APOLIPOPROTEIN B (Apo B) SECRETION | PFIZER (US) | 2003-03-05 | — | — | EP | claimed |