Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APOB | P04114 | 10/20 | 0.40 |
| ▸ | MTTP | P55157 | 9/20 | 0.40 |
| ▸ | FPR2 | P25090 | 3/20 | 0.40 |
| ▸ | SMO | Q99835 | 1/20 | 0.38 |
| ▸ | C5AR1 | P21730 | 1/20 | 0.36 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.35 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6970470 | 0.87 | MTTP (0.42) | APOBMTTPFPR2 | |
| SCHEMBL6966580 | 0.82 | SCN9A (0.43) | APOBMTTPSMOPRMT5WDR77 | |
| SCHEMBL6969570 | 0.79 | NPC1 (0.48) | APOBMTTPSMO | |
| SCHEMBL6962760 | 0.79 | APOB (0.44) | APOBMTTP | |
| SCHEMBL6973499 | 0.79 | SMO (0.45) | APOBMTTPSMO | |
| SCHEMBL6974662 | 0.78 | EPHX2 (0.45) | APOBMTTP | |
| SCHEMBL6970162 | 0.77 | NAMPT (0.47) | APOBMTTP | |
| SCHEMBL6964489 | 0.77 | SMO (0.50) | APOBMTTPSMO | |
| SCHEMBL6965865 | 0.77 | APOB (0.41) | APOBMTTPSMO | |
| SCHEMBL6967435 | 0.76 | APOB (0.41) | APOBMTTPSMOPRMT5WDR77 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0832069-B1 | BIPHENYL-2-CARBOXYLIC ACID-TETRAHYDRO-ISOQUINOLIN-6-YL AMIDE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS INHIBITORS OF MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN AND/OR APOLIPOPROTEIN B (Apo B) SECRETION | PFIZER (US) | 2003-03-05 | — | — | EP | claimed |