Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | SCN4A | P35499 | 1/20 | 0.42 |
| ▸ | CTSC | P53634 | 2/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.41 |
| ▸ | CTSD | P07339 | 1/20 | 0.41 |
| ▸ | HTR2C | P28335 | 1/20 | 0.40 |
| ▸ | HTR2B | P41595 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6968209 | 0.88 | L3MBTL1 (0.48) | POLBSCN4ACTSCSIGMAR1HTR2C | |
| SCHEMBL194737 | 0.79 | SCN4A (0.43) | POLBSCN4ACTSCSIGMAR1EPHX2 | |
| SCHEMBL7309838 | 0.78 | SCN4A (0.47) | POLBSCN4ACTSCHTR2CHTR2B | |
| SCHEMBL13436116 | 0.74 | MEN1 (0.53) | SCN4ACTSCHTR2CHTR2BKDM4E | |
| SCHEMBL28582403 | 0.73 | SCN4A (0.44) | SCN4ACTSCSIGMAR1HTR2CHTR2B | |
| Phenylacetic Acid SCHEMBL8787580 | 0.73 | AKR1B1 (0.50) | POLBCTSCEPHX2HTR2CHTR2B | |
| Phenylacetic Acid SCHEMBL8787583 | 0.73 | AKR1B1 (0.50) | POLBCTSCEPHX2HTR2CHTR2B | |
| SCHEMBL7707901 | 0.73 | CTSC (0.44) | SCN4ACTSCHTR2CALDH1A1 | |
| SCHEMBL7302727 | 0.72 | SCN4A (0.53) | POLBSCN4ACTSCHTR2CHTR2B | |
| SCHEMBL11127228 | 0.72 | POLB (0.51) | POLBCTSCEPHX2HTR2CHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1060178-B1 | HETEROCYCLIC COMPOUNDS AS INHIBITORS OF ROTAMASE ENZYMES | PFIZER (US) | 2003-09-03 | — | — | EP | disclosed |