Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 1/20 | 0.48 |
| ▸ | HTR1A | P08908 | 2/20 | 0.48 |
| ▸ | HTR7 | P34969 | 2/20 | 0.48 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.47 |
| ▸ | DRD2 | P14416 | 2/20 | 0.46 |
| ▸ | HTR2A | P28223 | 1/20 | 0.46 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.46 |
| ▸ | DRD4 | P21917 | 1/20 | 0.45 |
| ▸ | DRD3 | P35462 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6971856 | 0.98 | HTR1A (0.50) | CHRM1HTR1AHTR7HRH4 | |
| SCHEMBL6715841 | 0.94 | HRH4 (0.49) | HTR1AHTR7HRH4 | |
| SCHEMBL6712910 | 0.84 | DRD2 (0.48) | HTR1AHTR7HRH4DRD2DRD4 | |
| SCHEMBL6977709 | 0.80 | GRIN1 (0.66) | CHRM1HTR1AHTR7DRD2DRD4 | |
| SCHEMBL7084667 | 0.79 | HRH4 (0.51) | HTR1AHTR7HRH4DRD2DRD4 | |
| SCHEMBL7082418 | 0.78 | DRD2 (0.65) | CHRM1HTR1AHTR7DRD2HTR2A | |
| SCHEMBL6978625 | 0.78 | GRIN1 (0.58) | CHRM1HTR1AHTR7HRH4DRD2 | |
| SCHEMBL6715832 | 0.76 | HTR1A (0.63) | HTR1AHTR7HRH4DRD2DRD4 | |
| SCHEMBL6715989 | 0.76 | DRD2 (0.59) | CHRM1HTR1AHTR7HRH4DRD2 | |
| SCHEMBL6973851 | 0.74 | DRD2 (0.59) | HTR1AHRH4DRD2HTR2AMCHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1296954-A1 | BICYCLIC LACTAMS AND SULFONAMIDES WITH 5-HT1A-AFFINITY AND USE THEREOF FOR PREVENTING AND TREATING CEREBRAL ISCHAEMIA | Abbott GmbH & Co. KG (DE) | 2003-04-02 | — | — | EP | disclosed |
| WO-2002002529-A1 | BICYCLIC LACTAMS AND SULFONAMIDES WITH 5-HT1A-AFFINITY AND USE THEREOF FOR PREVENTING AND TREATING CEREBRAL ISCHAEMIA | ABBOTT GMBH & CO. KG (DE) | 2002-01-10 | — | — | WO | disclosed |