Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 6/20 | 0.59 |
| ▸ | HTR2A | P28223 | 5/20 | 0.59 |
| ▸ | MCHR1 | Q99705 | 4/20 | 0.59 |
| ▸ | HTR1A | P08908 | 2/20 | 0.55 |
| ▸ | HTR1D | P28221 | 1/20 | 0.55 |
| ▸ | HTR1B | P28222 | 1/20 | 0.55 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.55 |
| ▸ | DRD4 | P21917 | 1/20 | 0.54 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | DRD3 | P35462 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6711485 | 0.98 | DRD2 (0.57) | DRD2HTR2AMCHR1HTR1AHTR1D | |
| SCHEMBL7082418 | 0.94 | DRD2 (0.65) | DRD2HTR2AMCHR1HTR1AHTR1D | |
| SCHEMBL6714648 | 0.90 | HTR1A (0.49) | DRD2HTR2AMCHR1HTR1AHTR1D | |
| SCHEMBL7087322 | 0.87 | HRH4 (0.51) | DRD2HTR2AMCHR1HTR1AHTR1D | |
| SCHEMBL6715832 | 0.84 | HTR1A (0.63) | DRD2HTR1AHTR1DHTR1BSLC6A4 | |
| SCHEMBL6715989 | 0.83 | DRD2 (0.59) | DRD2HTR1ADRD4HRH4DRD3 | |
| SCHEMBL6711688 | 0.82 | HRH4 (0.52) | DRD2HTR1AHTR1DHTR1BSLC6A4 | |
| SCHEMBL14761628 | 0.82 | DRD4 (0.61) | DRD2HTR2AMCHR1HTR1ADRD4 | |
| SCHEMBL7084667 | 0.81 | HRH4 (0.51) | DRD2HTR1AHTR1DHTR1BSLC6A4 | |
| SCHEMBL6715841 | 0.80 | HRH4 (0.49) | HTR1AHTR1DHTR1BSLC6A4HRH4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1296954-A1 | BICYCLIC LACTAMS AND SULFONAMIDES WITH 5-HT1A-AFFINITY AND USE THEREOF FOR PREVENTING AND TREATING CEREBRAL ISCHAEMIA | Abbott GmbH & Co. KG (DE) | 2003-04-02 | — | — | EP | disclosed |
| WO-2002002529-A1 | BICYCLIC LACTAMS AND SULFONAMIDES WITH 5-HT1A-AFFINITY AND USE THEREOF FOR PREVENTING AND TREATING CEREBRAL ISCHAEMIA | ABBOTT GMBH & CO. KG (DE) | 2002-01-10 | — | — | WO | disclosed |