Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G2A | P14555 | 6/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | HTR6 | P50406 | 3/20 | 0.34 |
| ▸ | LTA4H | P09960 | 1/20 | 0.33 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6978340 | 0.92 | PLA2G2A (0.41) | PLA2G2ATSHRHTR6LTA4HTBXA2R | |
| SCHEMBL6983124 | 0.92 | PLA2G2A (0.40) | PLA2G2AHTR6 | |
| SCHEMBL8575157 | 0.87 | HTR6 (0.34) | HTR6 | |
| SCHEMBL818662 | 0.83 | PLA2G2A (0.42) | PLA2G2AHTR6 | |
| SCHEMBL8577109 | 0.79 | HTR6 (0.36) | PLA2G2ATSHRHTR6 | |
| SCHEMBL6978338 | 0.78 | HTR6 (0.36) | HTR6 | |
| SCHEMBL29862814 | 0.78 | PLA2G2A (0.45) | PLA2G2AHTR6 | |
| SCHEMBL818540 | 0.78 | PLA2G2A (0.45) | PLA2G2AHTR6 | |
| SCHEMBL6985524 | 0.78 | PLA2G2A (0.48) | PLA2G2ATSHRHTR6 | |
| SCHEMBL6985527 | 0.78 | PLA2G2A (0.48) | PLA2G2ATSHRHTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0839806-B1 | Substituted tricyclics | LILLY CO ELI (US) | 2003-07-09 | — | — | EP | disclosed |
| WO-1998018464-A1 | SUBSTITUTED TRICYCLICS | ELI LILLY AND COMPANY (US) | 1998-05-07 | — | — | WO | disclosed |
| EP-0839806-A1 | Substituted tricyclics | ELI LILLY AND COMPANY (US) | 1998-05-06 | — | — | EP | disclosed |