Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | NPC1 | O15118 | 3/20 | 0.39 |
| ▸ | RAB9A | P51151 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.36 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.35 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.35 |
| ▸ | HCAR2 | Q8TDS4 | 3/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6970690 | 0.88 | SMN1; SMN2 (0.43) | SMN1; SMN2NPC1RAB9ALMNAKMT2A | |
| SCHEMBL6967247 | 0.74 | POLB (0.38) | SMN1; SMN2NPC1RAB9ALMNAKMT2A | |
| SCHEMBL6969494 | 0.74 | GAA (0.36) | SMN1; SMN2NPC1RAB9ALMNAKMT2A | |
| SCHEMBL6154283 | 0.65 | KMT2A (0.53) | SMN1; SMN2NPC1RAB9ALMNAKMT2A | |
| SCHEMBL8247643 | 0.64 | SMN1; SMN2 (0.65) | SMN1; SMN2NPC1RAB9AKMT2AALDH1A1 | |
| SCHEMBL6155240 | 0.64 | MAPK1 (0.45) | SMN1; SMN2RAB9ALMNAKMT2AALDH1A1 | |
| SCHEMBL3632818 | 0.63 | SMN1; SMN2 (0.86) | SMN1; SMN2NPC1RAB9AKMT2AMAPK1 | |
| SCHEMBL6155187 | 0.63 | TSHR (0.40) | SMN1; SMN2RAB9ALMNAALDH1A1TSHR | |
| SCHEMBL18343349 | 0.62 | SMN1; SMN2 (0.51) | SMN1; SMN2NPC1RAB9AKMT2AALDH1A1 | |
| SCHEMBL10013763 | 0.60 | NPC1 (0.81) | SMN1; SMN2NPC1RAB9ALMNAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1329160-A2 | 4-ACYLAMINOPYRAZOLE DERIVATIVES | Sankyo Company, Limited (JP) | 2003-07-23 | — | — | EP | disclosed |