SCHEMBL6970846

SCHEMBL6970846

COc1ccc2[nH]nc(OS(=O)(=O)c3ccc(NC(C)=O)cc3)c2c1

nearest known ligand 0.53

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
MTNR1A P48039 1/20 0.53
MTNR1B P49286 1/20 0.53
ALDH1A1 P00352 7/20 0.51
LMNA P02545 5/20 0.51
SMN1; SMN2 Q16637 4/20 0.51
KDM4E B2RXH2 2/20 0.51
ITK Q08881 1/20 0.51
MEN1 O00255 3/20 0.50
KMT2A Q03164 3/20 0.50
TTK P33981 1/20 0.50
MAPK8 P45983 1/20 0.50
HTT P42858 1/20 0.49
MAPT P10636 2/20 0.48
RECQL P46063 1/20 0.48
HSP90AA1 P07900 1/20 0.47
IDO1 P14902 1/20 0.46
PTBP1 P26599 1/20 0.46
HPGD P15428 1/20 0.46
MAPK1 P28482 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6974868 0.86 TTK (0.50) ALDH1A1LMNASMN1; SMN2KDM4EITK
SCHEMBL6977777 0.84 PRKAG1 (0.46) ALDH1A1KDM4EMEN1KMT2ATTK
SCHEMBL6975273 0.83 MAPT (0.51) ALDH1A1LMNASMN1; SMN2KDM4EITK
SCHEMBL6966594 0.82 TTK (0.46) LMNASMN1; SMN2MEN1KMT2ATTK
SCHEMBL6970859 0.82 SMN1; SMN2 (0.49) ALDH1A1LMNASMN1; SMN2KDM4EITK
SCHEMBL6978830 0.79 TTK (0.44) LMNASMN1; SMN2MEN1KMT2ATTK
SCHEMBL6964917 0.75 CNR2 (0.66) ALDH1A1LMNASMN1; SMN2MEN1KMT2A
SCHEMBL6974524 0.71 TTK (0.45) ALDH1A1LMNASMN1; SMN2KDM4EITK
SCHEMBL6979256 0.70 FADS1 (0.45) TTK
SCHEMBL7082179 0.70 TTK (0.47) ALDH1A1KDM4EITKMEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1077947-B1 NOVEL 1,5 AND 3-O-SUBSTITUTED 1H-INDAZOLES WITH ANTI-ASTHMATIC, ANTI-ALLERGIC, ANTI-INFLAMMATORY, IMMUNO-MODULATING AND NEURO-PROTECTIVE EFFECT, METHOD FOR THE PRODUCTION AND USE THEREOF AS MEDICAMENTS DRESDEN ARZNEIMITTEL (DE) 2003-09-03 EP disclosed
EP-1077947-A1 NOVEL 1,5 AND 3-O-SUBSTITUTED 1H-INDAZOLES WITH ANTI-ASTHMATIC, ANTI-ALLERGIC, ANTI-INFLAMMATORY, IMMUNO-MODULATING AND NEURO-PROTECTIVE EFFECT, METHOD FOR THE PRODUCTION AND USE THEREOF AS MEDICAMENTS ARZNEIMITTELWERK DRESDEN GMBH (DE) 2001-02-28 EP disclosed
US-6166023-A 1,5- and 3-O-substituted 1H-indazoles having anti-asthmatic, anti-allergic, anti-inflammatory, immunomodulating and neuroprotective action, process for their preparation and their use as medicaments ARZNEIMITTELWERK DRESDEN GMBH (DE) 2000-12-26 US disclosed
WO-1999058503-A1 NOVEL 1,5 AND 3-O-SUBSTITUTED 1H-INDAZOLES WITH ANTI-ASTHMATIC, ANTI-ALLERGIC, ANTI-INFLAMMATORY, IMMUNO-MODULATING AND NEURO-PROTECTIVE EFFECT, METHOD FOR THE PRODUCTION AND USE THEREOF AS MEDICAMENTS ARZNEIMITTELWERK DRESDEN GMBH (DE) 1999-11-18 WO disclosed