Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | CTSK | P43235 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.35 |
| ▸ | ITGB1 | P05556 | 2/20 | 0.35 |
| ▸ | ITGA5 | P08648 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6977968 | 0.77 | RIPK1 (0.43) | — | |
| SCHEMBL6967927 | 0.73 | ITGB1 (0.37) | ITGB1ITGA5 | |
| SCHEMBL6967928 | 0.73 | ITGB1 (0.37) | ITGB1ITGA5 | |
| SCHEMBL7380863 | 0.70 | CRBN (0.37) | KMT2ACRBNMAPK1ALDH1A1SMN1; SMN2 | |
| SCHEMBL6977600 | 0.70 | CRBN (0.37) | KMT2ACRBNMAPK1ALDH1A1SMN1; SMN2 | |
| SCHEMBL6964149 | 0.69 | KMT2A (0.36) | KMT2ATSHRALDH1A1 | |
| SCHEMBL6964143 | 0.69 | KMT2A (0.36) | KMT2ATSHRALDH1A1 | |
| SCHEMBL6971327 | 0.69 | KMT2A (0.36) | KMT2ATSHRALDH1A1 | |
| SCHEMBL6977466 | 0.65 | CRBN (0.53) | KMT2ACRBNMAPK1ALDH1A1CTSK | |
| SCHEMBL6976609 | 0.65 | CRBN (0.53) | KMT2ACRBNMAPK1ALDH1A1CTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1023265-B1 | AZETIDINONE DERIVATIVES FOR THE TREATMENT OF HCMV INFECTIONS | BOEHRINGER INGELHEIM CA LTD (CA) | 2003-01-15 | — | — | EP | disclosed |
| US-6211170-B1 | Azetidinone derivatives for the treatment of HCMV infections | BOEHRINGER INGELHEIM (CANADA) LTD. (CA) | 2001-04-03 | — | — | US | disclosed |
| EP-1023265-A1 | AZETIDINONE DERIVATIVES FOR THE TREATMENT OF HCMV INFECTIONS | BOEHRINGER INGELHEIM (CANADA) LTD. (CA) | 2000-08-02 | — | — | EP | disclosed |
| WO-1999018073-A1 | AZETIDINONE DERIVATIVES FOR THE TREATMENT OF HCMV INFECTIONS | BOEHRINGER INGELHEIM (CANADA) LTD. (CA) | 1999-04-15 | — | — | WO | disclosed |