Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB1 | P05556 | 6/20 | 0.37 |
| ▸ | ITGA5 | P08648 | 5/20 | 0.37 |
| ▸ | ITGA4 | P13612 | 2/20 | 0.35 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.33 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.31 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.31 |
| ▸ | ITGAV | P06756 | 1/20 | 0.31 |
| ▸ | ITGAL | P20701 | 1/20 | 0.31 |
| ▸ | HCAR2 | Q8TDS4 | 2/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | BRD4 | O60885 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6967928 | 1.00 | ITGB1 (0.37) | ITGB1ITGA5ITGA4RIPK1ITGB3 | |
| SCHEMBL248703 | 0.74 | MME (0.43) | ITGB1ITGA5ITGA4RIPK1POLB | |
| SCHEMBL6970938 | 0.73 | KMT2A (0.42) | ITGB1ITGA5 | |
| SCHEMBL6686977 | 0.68 | POLB (0.36) | ITGB1ITGA5ITGA4POLBMAPT | |
| SCHEMBL6972069 | 0.68 | HRH3 (0.39) | — | |
| SCHEMBL26927141 | 0.65 | ALDH1A1 (0.32) | POLB | |
| SCHEMBL6689324 | 0.64 | CA12 (0.47) | ITGB1ITGA5MAPT | |
| SCHEMBL1849848 | 0.63 | RIPK1 (0.31) | RIPK1 | |
| SCHEMBL7386609 | 0.63 | FAAH (0.36) | — | |
| SCHEMBL7386611 | 0.63 | FAAH (0.36) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1023265-B1 | AZETIDINONE DERIVATIVES FOR THE TREATMENT OF HCMV INFECTIONS | BOEHRINGER INGELHEIM CA LTD (CA) | 2003-01-15 | — | — | EP | disclosed |
| US-6211170-B1 | Azetidinone derivatives for the treatment of HCMV infections | BOEHRINGER INGELHEIM (CANADA) LTD. (CA) | 2001-04-03 | — | — | US | disclosed |