SCHEMBL6971210

SCHEMBL6971210

O=C(O)C1(c2ccc(Cl)cc2)OCC2(CO1)c1ccccc1-c1ccccc12

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 1/20 0.41
CYP2C19 P33261 1/20 0.41
HIF1A Q16665 1/20 0.41
THRB P10828 1/20 0.39
TDP1 Q9NUW8 1/20 0.39
SMN1; SMN2 Q16637 4/20 0.39
HTT P42858 3/20 0.39
LMNA P02545 2/20 0.39
NPSR1 Q6W5P4 2/20 0.39
MDM2 Q00987 5/20 0.38
CYP2D6 P10635 3/20 0.37
HSD11B1 P28845 2/20 0.37
MEN1 O00255 1/20 0.36
XBP1 P17861 1/20 0.36
RAB9A P51151 1/20 0.36
KMT2A Q03164 1/20 0.36
ATM Q13315 1/20 0.36
PGR P06401 2/20 0.36
TP53 P04637 1/20 0.36
ADORA3 P0DMS8 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6982681 0.90 THRB (0.44) THRBTDP1NPSR1MEN1KMT2A
SCHEMBL6974413 0.86 HRH1 (0.37) CYP1A2CYP2C19HIF1ASMN1; SMN2HTT
SCHEMBL6982483 0.86 KIF11 (0.44) CYP1A2CYP2C19HIF1ASMN1; SMN2HTT
SCHEMBL6967893 0.85 CNR1 (0.40) HSD11B1KMT2A
SCHEMBL7145811 0.85 APP (0.38) SMN1; SMN2HTTLMNAMEN1KMT2A
SCHEMBL377756 0.84 MAPK1 (0.40) HSD11B1KMT2ASLC6A2SLC6A4SLC6A3
SCHEMBL6971971 0.83 NPC1 (0.44) RAB9AKMT2ATP53SLC6A2SLC6A4
SCHEMBL7816365 0.82 MAPT (0.40) CYP2C19TDP1SMN1; SMN2LMNANPSR1
SCHEMBL6978137 0.81 OPRM1 (0.43) SMN1; SMN2HTTLMNANPSR1MDM2
SCHEMBL6971212 0.80 CYP1A2 (0.39) CYP1A2CYP2C19HIF1ATHRBTDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1098893-B1 CYCLIC COMPOUNDS USEFUL IN THE TREATMENT OF DYSLIPIDEMIA, ATHEROSCLEROSIS AND DIABETES, PHARMACEUTICAL COMPOSITIONS AND PREPARATION PROCESS MERCK PATENT GMBH (DE) 2003-03-26 EP claimed
US-6528538-B1 Reaction of 1,3-propanediol derivative with a ketone or aldehyde MERCK PATENTGESELLSCHAFT (DE) 2003-03-04 US claimed
EP-1098893-A1 CYCLIC COMPOUNDS USEFUL IN THE TREATMENT OF DYSLIPIDEMIA, ATHEROSCLEROSIS AND DIABETES, PHARMACEUTICAL COMPOSITIONS AND PREPARATION PROCESS MERCK PATENT GmbH (DE) 2001-05-16 EP claimed
WO-2000004011-A1 CYCLIC COMPOUNDS USEFUL IN THE TREATMENT OF DYSLIPIDAEMIA, ATHEROSCLEROSIS AND DIABETES, PHARMACEUTICAL COMPOSITIONS AND PREPARATION PROCESS MERCK PATENT GMBH (DE) 2000-01-27 WO claimed
EP-1098893-B1 CYCLIC COMPOUNDS USEFUL IN THE TREATMENT OF DYSLIPIDEMIA, ATHEROSCLEROSIS AND DIABETES, PHARMACEUTICAL COMPOSITIONS AND PREPARATION PROCESS MERCK PATENT GMBH (DE) 2003-03-26 EP disclosed