Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 1/20 | 0.49 |
| ▸ | BCHE | P06276 | 7/20 | 0.49 |
| ▸ | ACHE | P22303 | 7/20 | 0.49 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.46 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.46 |
| ▸ | CHRNA10 | Q9GZZ6 | 1/20 | 0.46 |
| ▸ | CHRNA9 | Q9UGM1 | 1/20 | 0.46 |
| ▸ | PPARG | P37231 | 1/20 | 0.45 |
| ▸ | RELA | Q04206 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6971511 | 1.00 | MAOB (0.49) | MAOBBCHEACHECHRNA7MEN1 | |
| SCHEMBL6968829 | 0.80 | PPARG (0.60) | MAOBPPARGHPGD | |
| SCHEMBL6968833 | 0.80 | PPARG (0.60) | MAOBPPARGHPGD | |
| SCHEMBL6967717 | 0.80 | TSHR (0.69) | MAOBMEN1KMT2ATSHR | |
| SCHEMBL7451250 | 0.78 | ALDH1A1 (0.58) | MAOBMAPTTSHRKDM4EALDH1A1 | |
| SCHEMBL12507451 | 0.77 | MEN1 (0.73) | MAOBBCHEACHEMEN1KMT2A | |
| SCHEMBL6976723 | 0.76 | LTA4H (0.55) | MAPTTSHRALDH1A1HPGD | |
| SCHEMBL9326189 | 0.76 | PPARG (0.50) | MAOBBCHEACHEPPARGMAPT | |
| SCHEMBL9522631 | 0.75 | PPARG (0.55) | MAOBMEN1KMT2APPARGRELA | |
| SCHEMBL9522633 | 0.75 | PPARG (0.55) | MAOBMEN1KMT2APPARGRELA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0801063-B1 | Thiazolidinedione derivatives having antidiabetic, hypolipidaemic, antihypertensive properties, process for their preparation and pharmaceutical compositions containing them | REDDYS LAB LTD DR (IN) | 2003-01-15 | — | — | EP | disclosed |
| EP-0801063-A1 | Thiazolidinedione derivatives having antidiabetic, hypolipidaemic antihypertensive properties, process for their preparation and pharmaceutical compositions containing them | DR. REDDY'S RESEARCH FOUNDATION (IN) | 1997-10-15 | — | — | EP | disclosed |