Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.48 |
| ▸ | POLB | P06746 | 4/20 | 0.48 |
| ▸ | ATM | Q13315 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.42 |
| ▸ | APP | P05067 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.41 |
| ▸ | RECQL | P46063 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 3/20 | 0.40 |
| ▸ | PGR | P06401 | 1/20 | 0.40 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31482993 | 0.84 | PTGS2 (0.53) | KDM4EPOLBATMHSD17B10ALDH1A1 | |
| SCHEMBL10607461 | 0.84 | PTGS2 (0.53) | KDM4EPOLBATMHSD17B10ALDH1A1 | |
| SCHEMBL6971092 | 0.81 | HSD17B10 (0.64) | KDM4EPOLBHSD17B10ALDH1A1SMN1; SMN2 | |
| SCHEMBL24260613 | 0.79 | ELANE (0.47) | KDM4EPOLBATMHSD17B10APP | |
| SCHEMBL24260332 | 0.79 | HSD17B10 (0.46) | KDM4EPOLBATMHSD17B10APP | |
| SCHEMBL12457107 | 0.75 | CYP2C19 (0.49) | KDM4EPOLBATMHSD17B10APP | |
| SCHEMBL2496240 | 0.74 | APP (0.44) | KDM4EPOLBATMHSD17B10APP | |
| SCHEMBL6959171 | 0.74 | NPC1 (0.59) | POLBSMN1; SMN2MAPK1HPGDKMT2A | |
| SCHEMBL9808651 | 0.74 | TDP2 (0.45) | KDM4EPOLBHSD17B10GAAKMT2A | |
| SCHEMBL6240378 | 0.73 | APP (0.48) | KDM4EPOLBATMHSD17B10APP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1329160-A2 | 4-ACYLAMINOPYRAZOLE DERIVATIVES | Sankyo Company, Limited (JP) | 2003-07-23 | — | — | EP | disclosed |