Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 13/20 | 0.36 |
| ▸ | RAB9A | P51151 | 10/20 | 0.36 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.36 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 3/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | TNF | P01375 | 1/20 | 0.33 |
| ▸ | KLF5 | Q13887 | 1/20 | 0.33 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.32 |
| ▸ | MAPT | P10636 | 3/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | POLB | P06746 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | CASP3 | P42574 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6972037 | 1.00 | NPC1 (0.36) | NPC1RAB9ACDK5CDK5R1NPSR1 | |
| SCHEMBL752930 | 0.81 | MAPT (0.42) | NPC1RAB9ACDK5CDK5R1MEN1 | |
| SCHEMBL752931 | 0.81 | MAPT (0.42) | NPC1RAB9ACDK5CDK5R1MEN1 | |
| SCHEMBL696077 | 0.80 | L3MBTL1 (0.39) | NPC1RAB9ACDK5CDK5R1SMN1; SMN2 | |
| SCHEMBL696078 | 0.80 | L3MBTL1 (0.39) | NPC1RAB9ACDK5CDK5R1SMN1; SMN2 | |
| SCHEMBL6970352 | 0.80 | L3MBTL1 (0.39) | NPC1RAB9ACDK5CDK5R1SMN1; SMN2 | |
| SCHEMBL6972819 | 0.77 | ALDH1A1 (0.36) | KMT2ASMN1; SMN2MAPTLMNAPOLB | |
| SCHEMBL6972825 | 0.77 | ALDH1A1 (0.36) | KMT2ASMN1; SMN2MAPTLMNAPOLB | |
| SCHEMBL5182951 | 0.77 | NPC1 (0.37) | NPC1RAB9ACDK5CDK5R1NPSR1 | |
| SCHEMBL5182946 | 0.77 | NPC1 (0.37) | NPC1RAB9ACDK5CDK5R1NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1329160-A2 | 4-ACYLAMINOPYRAZOLE DERIVATIVES | Sankyo Company, Limited (JP) | 2003-07-23 | — | — | EP | disclosed |