Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.35 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.35 |
| ▸ | CCR3 | P51677 | 2/20 | 0.34 |
| ▸ | PDE2A | O00408 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6974191 | 0.87 | YAP1 (0.35) | — | |
| SCHEMBL10639237 | 0.85 | PDE2A (0.38) | CYP11B1CYP11B2PDE2A | |
| SCHEMBL9540445 | 0.77 | FFAR1 (0.43) | CYP11B1CYP11B2PDE2A | |
| SCHEMBL6977874 | 0.77 | ALDH1A1 (0.43) | MAPT | |
| SCHEMBL10641500 | 0.74 | THRB (0.38) | — | |
| SCHEMBL10642125 | 0.74 | CYP11B1 (0.39) | CYP11B1CYP11B2PDE2A | |
| SCHEMBL10639514 | 0.71 | CNR2 (0.37) | — | |
| SCHEMBL10639565 | 0.71 | ALDH1A1 (0.34) | MAPT | |
| SCHEMBL10640166 | 0.71 | FFAR1 (0.41) | — | |
| SCHEMBL10637004 | 0.70 | SLC6A2 (0.41) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0821674-B1 | CYCLIC AMIDINO AGENTS USEFUL AS NITRIC OXIDE SYNTHASE INHIBITORS | SEARLE & CO (US) | 2003-08-06 | — | — | EP | disclosed |
| US-6011028-A | Cyclic amidino agents useful as nitric oxide synthase inhibitors | G.D. SEARLE & CO. (US) | 2000-01-04 | — | — | US | disclosed |
| US-5883251-A | ENZYME INHIBITORS | G. D. SEARLE & CO. (US) | 1999-03-16 | — | — | US | disclosed |
| EP-0821674-A1 | CYCLIC AMIDINO AGENTS USEFUL AS NITRIC OXIDE SYNTHASE INHIBITORS | G.D. SEARLE & CO. (US) | 1998-02-04 | — | — | EP | disclosed |