Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.39 |
| ▸ | PLK1 | P53350 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | S1PR3 | Q99500 | 2/20 | 0.35 |
| ▸ | HPGDS | O60760 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.34 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.34 |
| ▸ | GSK3A | P49840 | 1/20 | 0.34 |
| ▸ | EP300 | Q09472 | 2/20 | 0.34 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.34 |
| ▸ | CNR1 | P21554 | 1/20 | 0.34 |
| ▸ | CNR2 | P34972 | 1/20 | 0.34 |
| ▸ | GPR139 | Q6DWJ6 | 1/20 | 0.33 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.33 |
| ▸ | AKT2 | P31751 | 1/20 | 0.33 |
| ▸ | MGLL | Q99685 | 1/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6972370 | 0.71 | S1PR1 (0.36) | LRRK2PLK1SMN1; SMN2MAPK1PIN1 | |
| SCHEMBL22927647 | 0.66 | HPGDS (0.42) | SMN1; SMN2S1PR3HPGDSCNR1CNR2 | |
| SCHEMBL17069277 | 0.64 | TSHR (0.48) | CNR1CNR2GPR139SLC6A2SLC6A4 | |
| SCHEMBL17071849 | 0.64 | TSHR (0.48) | CNR1CNR2GPR139SLC6A2SLC6A4 | |
| SCHEMBL22927646 | 0.64 | HPGDS (0.40) | SMN1; SMN2S1PR3HPGDSCNR1CNR2 | |
| SCHEMBL28716544 | 0.64 | HPGDS (0.40) | SMN1; SMN2S1PR3HPGDSCNR1CNR2 | |
| SCHEMBL28716543 | 0.64 | HPGDS (0.40) | SMN1; SMN2S1PR3HPGDSCNR1CNR2 | |
| SCHEMBL24963400 | 0.63 | CHEK1 (0.57) | PIN1MAP4K4GSK3ACHEK1AKT2 | |
| SCHEMBL30239372 | 0.63 | CHEK1 (0.57) | PIN1MAP4K4GSK3ACHEK1AKT2 | |
| SCHEMBL17069276 | 0.62 | TSHR (0.45) | CNR1CNR2GPR139MGLLSLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1329160-A2 | 4-ACYLAMINOPYRAZOLE DERIVATIVES | Sankyo Company, Limited (JP) | 2003-07-23 | — | — | EP | disclosed |