Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 2/20 | 0.36 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.33 |
| ▸ | EP300 | Q09472 | 2/20 | 0.33 |
| ▸ | KCNN4 | O15554 | 1/20 | 0.32 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.32 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.32 |
| ▸ | PLK1 | P53350 | 1/20 | 0.32 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | HTT | P42858 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | CRHBP | P24387 | 1/20 | 0.32 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.31 |
| ▸ | AKT2 | P31751 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6972138 | 0.71 | LRRK2 (0.39) | LRRK2EP300PIN1PLK1SLC6A2 | |
| SCHEMBL6972363 | 0.66 | S1PR1 (0.36) | S1PR1LRRK2KCNA5 | |
| SCHEMBL6966470 | 0.66 | MEP1A (0.44) | PIN1SLC6A2SLC6A4LMNA | |
| SCHEMBL13367360 | 0.64 | KCNA5 (0.46) | S1PR1KCNN4KCNA5ALDH1A1HTT | |
| SCHEMBL7093358 | 0.64 | LMNA (0.50) | ALDH1A1LMNATSHRSMN1; SMN2 | |
| SCHEMBL6971350 | 0.64 | MEP1A (0.44) | PIN1SLC6A2SLC6A4 | |
| SCHEMBL7095374 | 0.63 | IDO1 (0.42) | ALDH1A1LMNATSHRSMN1; SMN2 | |
| SCHEMBL17069276 | 0.63 | TSHR (0.45) | S1PR1SLC6A2SLC6A4ALDH1A1TSHR | |
| SCHEMBL17069277 | 0.62 | TSHR (0.48) | S1PR1SLC6A2SLC6A4ALDH1A1TSHR | |
| SCHEMBL11601064 | 0.62 | TSHR (0.48) | SLC6A2SLC6A4ALDH1A1HTTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1329160-A2 | 4-ACYLAMINOPYRAZOLE DERIVATIVES | Sankyo Company, Limited (JP) | 2003-07-23 | — | — | EP | disclosed |