Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 4/20 | 0.40 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.39 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.39 |
| ▸ | BCL2 | P10415 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | ACHE | P22303 | 2/20 | 0.37 |
| ▸ | CNR2 | P34972 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | CNR1 | P21554 | 1/20 | 0.37 |
| ▸ | PTGES | O14684 | 1/20 | 0.36 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.36 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6975027 | 0.81 | HTR6 (0.45) | HTR6AKR1C3AKR1C2TP53ALDH1A1 | |
| SCHEMBL6967847 | 0.79 | ALDH1A1 (0.45) | HTR6POLBLMNAALDH1A1MAPT | |
| SCHEMBL6965738 | 0.79 | MAPT (0.44) | HTR6TP53ALDH1A1MAPTKDM4E | |
| SCHEMBL6972954 | 0.78 | HTR6 (0.42) | HTR6BCL2POLBLMNAALDH1A1 | |
| SCHEMBL6975974 | 0.77 | AKR1C3 (0.48) | HTR6AKR1C3AKR1C2LMNATP53 | |
| SCHEMBL6975698 | 0.77 | HTR6 (0.39) | HTR6TP53ALDH1A1MAPTACHE | |
| SCHEMBL6966140 | 0.77 | ALDH1A1 (0.50) | HTR6POLBLMNAALDH1A1MAPT | |
| SCHEMBL6968667 | 0.77 | HTR6 (0.48) | HTR6AKR1C3AKR1C2POLBLMNA | |
| SCHEMBL6969760 | 0.76 | AKR1C3 (0.39) | HTR6AKR1C3AKR1C2TP53ALDH1A1 | |
| SCHEMBL6970702 | 0.76 | HTR6 (0.47) | HTR6AKR1C3AKR1C2POLBLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1077947-B1 | NOVEL 1,5 AND 3-O-SUBSTITUTED 1H-INDAZOLES WITH ANTI-ASTHMATIC, ANTI-ALLERGIC, ANTI-INFLAMMATORY, IMMUNO-MODULATING AND NEURO-PROTECTIVE EFFECT, METHOD FOR THE PRODUCTION AND USE THEREOF AS MEDICAMENTS | DRESDEN ARZNEIMITTEL (DE) | 2003-09-03 | — | — | EP | claimed |