Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP3 | P08254 | 5/20 | 0.50 |
| ▸ | USP5 | P45974 | 8/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.40 |
| ▸ | CNR1 | P21554 | 2/20 | 0.40 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.40 |
| ▸ | MMP2 | P08253 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | MMP1 | P03956 | 1/20 | 0.38 |
| ▸ | MMP9 | P14780 | 1/20 | 0.38 |
| ▸ | MMP14 | P50281 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6434485 | 0.87 | MMP3 (0.47) | MMP3USP5HDAC6CNR1MMP2 | |
| SCHEMBL6433458 | 0.80 | PDE4B (0.43) | ALDH1A1 | |
| SCHEMBL6961774 | 0.80 | PTGDR (0.39) | MMP3USP5HDAC6PTGDRMMP2 | |
| SCHEMBL6966717 | 0.76 | MAPT (0.36) | MMP3USP5HDAC6PTGDRMMP2 | |
| SCHEMBL6966720 | 0.76 | MAPT (0.36) | MMP3USP5HDAC6PTGDRMMP2 | |
| SCHEMBL7204028 | 0.76 | MAPT (0.38) | MMP3USP5HDAC6PTGDRMMP2 | |
| SCHEMBL6966714 | 0.76 | MAPT (0.36) | MMP3USP5HDAC6PTGDRMMP2 | |
| SCHEMBL6437658 | 0.74 | MMP2 (0.51) | MMP3USP5MMP2MMP1MMP9 | |
| SCHEMBL7204026 | 0.74 | KMT2A (0.38) | MMP3PTGDRMMP2MMP1MMP9 | |
| SCHEMBL6435225 | 0.73 | MMP3 (0.38) | MMP3USP5MMP2MMP1MMP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1181017-B1 | METALLOPROTEASE INHIBITORS | PFIZER LTD (GB) | 2003-04-16 | — | — | EP | claimed |