Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 3/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | LSS | P48449 | 1/20 | 0.36 |
| ▸ | CCR3 | P51677 | 1/20 | 0.36 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | DRD4 | P21917 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ESR1 | P03372 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6966767 | 0.79 | LSS (0.37) | CYP3A4CYP2D6CYP2C9TSHRUSP2 | |
| SCHEMBL6967328 | 0.77 | CCR3 (0.36) | CYP2D6TSHRCCR3OPRL1OPRM1 | |
| SCHEMBL6976709 | 0.76 | CCR3 (0.45) | CYP3A4CYP2D6CYP2C9TSHRCCR3 | |
| SCHEMBL6968225 | 0.76 | SMN1; SMN2 (0.42) | CCR3OPRL1ALDH1A1DRD4LMNA | |
| SCHEMBL6967295 | 0.76 | CCR3 (0.42) | CCR3OPRL1ALDH1A1DRD4SIGMAR1 | |
| SCHEMBL6973584 | 0.72 | SIGMAR1 (0.40) | CCR3ALDH1A1DRD4SIGMAR1KDM4E | |
| SCHEMBL6969244 | 0.72 | CHKA (0.45) | ALDH1A1DRD4SIGMAR1KDM4EDRD2 | |
| SCHEMBL6977411 | 0.72 | CCR3 (0.41) | CCR3OPRL1ALDH1A1DRD4LMNA | |
| SCHEMBL6976116 | 0.72 | CCR3 (0.46) | CCR3OPRL1OPRM1ALDH1A1DRD4 | |
| SCHEMBL6975673 | 0.72 | CYP2D6 (0.45) | CYP2D6TSHRCCR3ALDH1A1DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1202984-B1 | DIPHENYL-PIPERIDINE DERIVATE | ASTRAZENECA UK LTD (GB) | 2003-03-05 | — | — | EP | claimed |