Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.59 |
| ▸ | RAB9A | P51151 | 5/20 | 0.59 |
| ▸ | NPC1 | O15118 | 4/20 | 0.59 |
| ▸ | GPR174 | Q9BXC1 | 1/20 | 0.59 |
| ▸ | ITGB1 | P05556 | 3/20 | 0.57 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.57 |
| ▸ | ITGAV | P06756 | 2/20 | 0.57 |
| ▸ | ITGA5 | P08648 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.56 |
| ▸ | MEN1 | O00255 | 4/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.56 |
| ▸ | PTPN12 | Q05209 | 1/20 | 0.56 |
| ▸ | HTT | P42858 | 1/20 | 0.56 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.55 |
| ▸ | DDX3X | O00571 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | PKM | P14618 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1305413 | 0.85 | KMT2A (0.75) | MAPTNPC1GPR174KMT2AMEN1 | |
| SCHEMBL6982577 | 0.84 | KMT2A (0.66) | MAPTRAB9ANPC1GPR174KMT2A | |
| SCHEMBL6983400 | 0.84 | MEN1 (0.70) | MAPTRAB9ANPC1GPR174KMT2A | |
| SCHEMBL6975863 | 0.84 | KMT2A (0.53) | MAPTRAB9ANPC1GPR174ITGB1 | |
| SCHEMBL6982728 | 0.83 | DDX3X (0.58) | MAPTRAB9ANPC1ITGB1ITGB3 | |
| SCHEMBL6983315 | 0.83 | MAPT (0.47) | MAPTRAB9ANPC1GPR174ITGB1 | |
| SCHEMBL6983832 | 0.83 | RAB9A (0.58) | MAPTRAB9ANPC1GPR174KMT2A | |
| SCHEMBL6978447 | 0.82 | MAPT (0.60) | MAPTRAB9ANPC1KMT2AMEN1 | |
| SCHEMBL6979807 | 0.82 | POLB (0.56) | RAB9ANPC1ITGB1ITGB3ITGAV | |
| SCHEMBL17079626 | 0.81 | RAB9A (0.73) | MAPTRAB9ANPC1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1030835-B1 | UREA DERIVATIVES AND THEIR USE AS INTEGRIN INHIBITORS | ASTRAZENECA UK LTD (GB) | 2003-01-22 | — | — | EP | disclosed |
| US-6344570-B1 | ANTISTICKING AGENTS FOR CELLS | ASTRAZENECA UK LIMITED (GB) | 2002-02-05 | — | — | US | disclosed |
| EP-1030835-A2 | UREA DERIVATIVES AND THEIR USE AS INTEGRIN INHIBITORS | AstraZeneca UK Limited (GB) | 2000-08-30 | — | — | EP | disclosed |
| WO-1999024398-A2 | UREA DERIVATIVES AND THEIR USE AS INTEGRIN INHIBITORS | ASTRAZENECA UK LIMITED (GB) | 1999-05-20 | — | — | WO | disclosed |