Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DDX3X | O00571 | 3/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | ITGB1 | P05556 | 4/20 | 0.53 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.53 |
| ▸ | ITGAV | P06756 | 1/20 | 0.53 |
| ▸ | ITGA5 | P08648 | 1/20 | 0.53 |
| ▸ | ITGA4 | P13612 | 3/20 | 0.53 |
| ▸ | RAB9A | P51151 | 4/20 | 0.52 |
| ▸ | NPC1 | O15118 | 3/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.49 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.49 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6971221 | 0.86 | RAB9A (0.55) | DDX3XALDH1A1ITGB1ITGB3ITGAV | |
| SCHEMBL6979953 | 0.84 | DDX3X (0.57) | DDX3XALDH1A1LMNASMN1; SMN2RAB9A | |
| SCHEMBL6973229 | 0.83 | MAPT (0.59) | DDX3XALDH1A1SMN1; SMN2ITGB1ITGB3 | |
| SCHEMBL10814720 | 0.80 | HPGD (0.54) | ALDH1A1LMNAMAPTMEN1KMT2A | |
| SCHEMBL17079628 | 0.78 | MEN1 (0.71) | DDX3XALDH1A1LMNASMN1; SMN2RAB9A | |
| SCHEMBL6106511 | 0.77 | TDP1 (0.51) | ALDH1A1POLBPPARGPPARD | |
| SCHEMBL5309963 | 0.76 | KMT2A (0.58) | ALDH1A1LMNASMN1; SMN2RAB9ANPC1 | |
| SCHEMBL1659299 | 0.75 | DDX3X (1.00) | DDX3XALDH1A1LMNASMN1; SMN2ITGB1 | |
| SCHEMBL11918074 | 0.75 | DDX3X (1.00) | DDX3XALDH1A1LMNASMN1; SMN2ITGB1 | |
| SCHEMBL812756 | 0.74 | DDX3X (0.80) | DDX3XALDH1A1LMNASMN1; SMN2ITGB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1030835-B1 | UREA DERIVATIVES AND THEIR USE AS INTEGRIN INHIBITORS | ASTRAZENECA UK LTD (GB) | 2003-01-22 | — | — | EP | disclosed |
| US-6344570-B1 | ANTISTICKING AGENTS FOR CELLS | ASTRAZENECA UK LIMITED (GB) | 2002-02-05 | — | — | US | disclosed |
| EP-1030835-A2 | UREA DERIVATIVES AND THEIR USE AS INTEGRIN INHIBITORS | AstraZeneca UK Limited (GB) | 2000-08-30 | — | — | EP | disclosed |
| WO-1999024398-A2 | UREA DERIVATIVES AND THEIR USE AS INTEGRIN INHIBITORS | ASTRAZENECA UK LIMITED (GB) | 1999-05-20 | — | — | WO | disclosed |