Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.47 |
| ▸ | RAB9A | P51151 | 3/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | ITGB1 | P05556 | 7/20 | 0.47 |
| ▸ | ITGA4 | P13612 | 6/20 | 0.47 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.46 |
| ▸ | ITGAV | P06756 | 1/20 | 0.46 |
| ▸ | ITGA5 | P08648 | 1/20 | 0.46 |
| ▸ | GPR174 | Q9BXC1 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 4/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | DDX3X | O00571 | 1/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.43 |
| ▸ | PPARA | Q07869 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6973229 | 0.83 | MAPT (0.59) | MAPTRAB9ANPC1ITGB1ITGA4 | |
| SCHEMBL6975863 | 0.73 | KMT2A (0.53) | MAPTRAB9ANPC1ITGB1ITGA4 | |
| SCHEMBL6983832 | 0.70 | RAB9A (0.58) | MAPTRAB9ANPC1GPR174MEN1 | |
| SCHEMBL1305413 | 0.70 | KMT2A (0.75) | MAPTNPC1GPR174MAPK1MEN1 | |
| SCHEMBL17079626 | 0.69 | RAB9A (0.73) | MAPTRAB9ANPC1MAPK1MEN1 | |
| SCHEMBL6982577 | 0.69 | KMT2A (0.66) | MAPTRAB9ANPC1GPR174MAPK1 | |
| SCHEMBL6983400 | 0.69 | MEN1 (0.70) | MAPTRAB9ANPC1GPR174MAPK1 | |
| SCHEMBL812756 | 0.69 | DDX3X (0.80) | MAPTRAB9ANPC1ITGB1ITGB3 | |
| SCHEMBL6982728 | 0.69 | DDX3X (0.58) | MAPTRAB9ANPC1ITGB1ITGA4 | |
| SCHEMBL6794878 | 0.68 | ITGB1 (0.62) | MAPTRAB9ANPC1ITGB1ITGA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1030835-B1 | UREA DERIVATIVES AND THEIR USE AS INTEGRIN INHIBITORS | ASTRAZENECA UK LTD (GB) | 2003-01-22 | — | — | EP | disclosed |
| US-6344570-B1 | ANTISTICKING AGENTS FOR CELLS | ASTRAZENECA UK LIMITED (GB) | 2002-02-05 | — | — | US | disclosed |
| EP-1030835-A2 | UREA DERIVATIVES AND THEIR USE AS INTEGRIN INHIBITORS | AstraZeneca UK Limited (GB) | 2000-08-30 | — | — | EP | disclosed |
| WO-1999024398-A2 | UREA DERIVATIVES AND THEIR USE AS INTEGRIN INHIBITORS | ASTRAZENECA UK LIMITED (GB) | 1999-05-20 | — | — | WO | disclosed |