SCHEMBL6973761

SCHEMBL6973761

CC(C)c1nc(C=O)n(Cc2ccccn2)c1Sc1cccc([N+](=O)[O-])c1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CFTR P13569 1/20 0.44
S1PR3 Q99500 1/20 0.38
L3MBTL1 Q9Y468 2/20 0.37
CYP1A2 P05177 1/20 0.37
CYP3A4 P08684 1/20 0.37
MAPT P10636 5/20 0.36
ALDH1A1 P00352 3/20 0.36
SMN1; SMN2 Q16637 3/20 0.36
NPC1 O15118 2/20 0.36
RAB9A P51151 2/20 0.36
MAPK1 P28482 1/20 0.36
LMNA P02545 2/20 0.35
PKM P14618 1/20 0.35
POLB P06746 1/20 0.35
GAA P10253 1/20 0.35
HPGD P15428 1/20 0.35
HSP90AA1 P07900 1/20 0.34
KMT2A Q03164 2/20 0.34
KDM4E B2RXH2 1/20 0.33
MEN1 O00255 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6964470 0.90 CFTR (0.42) CFTRS1PR3L3MBTL1CYP1A2CYP3A4
SCHEMBL6964467 0.90 CFTR (0.42) CFTRS1PR3L3MBTL1CYP1A2CYP3A4
SCHEMBL6972931 0.86 CFTR (0.44) CFTRS1PR3L3MBTL1CYP1A2CYP3A4
SCHEMBL6969838 0.86 CFTR (0.44) CFTRS1PR3L3MBTL1CYP1A2CYP3A4
SCHEMBL6973368 0.86 ALDH1A1 (0.34) CYP1A2ALDH1A1SMN1; SMN2NPC1RAB9A
SCHEMBL6966500 0.85 PDE4A (0.39) L3MBTL1CYP1A2CYP3A4MAPTALDH1A1
SCHEMBL6973903 0.85 GRIN1 (0.38) L3MBTL1MAPTALDH1A1SMN1; SMN2PKM
SCHEMBL6967288 0.85 GRIN1 (0.40) S1PR3KMT2AKDM4E
SCHEMBL6973701 0.85 SMN1; SMN2 (0.40) CFTRL3MBTL1CYP1A2MAPTALDH1A1
SCHEMBL6973370 0.84 CFTR (0.43) CFTRS1PR3L3MBTL1CYP1A2CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0786455-B1 IMIDAZOLE DERIVATIVE SHIONOGI & CO (JP) 2003-12-03 EP disclosed
US-6147097-A METHOD FOR TREATING AIDS SHIONOGI & CO., LTD. (JP) 2000-11-14 US disclosed
US-5910506-A IMIDAZOLE DERIVATIVES, E.G.5-(3,5-DICHLOROPHENYLTHIO)-1,2-DIMETHYL-4-ISOPROPYL-1H-IMIDAZOLE; VIRICIDES; AIDS; NONTOXIC SHIONOGI & CO., LTD. (JP) 1999-06-08 US disclosed