Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.51 |
| ▸ | HTR1A | P08908 | 4/20 | 0.50 |
| ▸ | HTR1B | P28222 | 2/20 | 0.50 |
| ▸ | HTR1D | P28221 | 1/20 | 0.50 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.50 |
| ▸ | HTR7 | P34969 | 2/20 | 0.48 |
| ▸ | DRD2 | P14416 | 2/20 | 0.44 |
| ▸ | HTR2A | P28223 | 1/20 | 0.44 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.44 |
| ▸ | DRD4 | P21917 | 1/20 | 0.44 |
| ▸ | DRD3 | P35462 | 1/20 | 0.44 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.43 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.43 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6715832 | 0.88 | HTR1A (0.63) | HRH4HTR1AHTR1BHTR1DSLC6A4 | |
| SCHEMBL6973851 | 0.87 | DRD2 (0.59) | HRH4HTR1AHTR1BHTR1DSLC6A4 | |
| SCHEMBL6711688 | 0.87 | HRH4 (0.52) | HRH4HTR1AHTR1BHTR1DSLC6A4 | |
| SCHEMBL6715989 | 0.87 | DRD2 (0.59) | HRH4HTR1AHTR7DRD2DRD4 | |
| Hydrochloric Acid SCHEMBL6711485 | 0.85 | DRD2 (0.57) | HRH4HTR1AHTR1BHTR1DSLC6A4 | |
| SCHEMBL7084667 | 0.84 | HRH4 (0.51) | HRH4HTR1AHTR1BHTR1DSLC6A4 | |
| SCHEMBL7082418 | 0.81 | DRD2 (0.65) | HTR1AHTR1BHTR1DSLC6A4HTR7 | |
| SCHEMBL6978625 | 0.81 | GRIN1 (0.58) | HRH4HTR1AHTR7DRD2DRD4 | |
| SCHEMBL6977709 | 0.81 | GRIN1 (0.66) | HTR1AHTR7DRD2DRD4DRD3 | |
| SCHEMBL6714648 | 0.79 | HTR1A (0.49) | HRH4HTR1AHTR1BHTR1DSLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1296954-A1 | BICYCLIC LACTAMS AND SULFONAMIDES WITH 5-HT1A-AFFINITY AND USE THEREOF FOR PREVENTING AND TREATING CEREBRAL ISCHAEMIA | Abbott GmbH & Co. KG (DE) | 2003-04-02 | — | — | EP | disclosed |
| WO-2002002529-A1 | BICYCLIC LACTAMS AND SULFONAMIDES WITH 5-HT1A-AFFINITY AND USE THEREOF FOR PREVENTING AND TREATING CEREBRAL ISCHAEMIA | ABBOTT GMBH & CO. KG (DE) | 2002-01-10 | — | — | WO | disclosed |