Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.58 |
| ▸ | HTR6 | P50406 | 4/20 | 0.55 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | ESR1 | P03372 | 1/20 | 0.51 |
| ▸ | AR | P10275 | 1/20 | 0.51 |
| ▸ | IKBKB | O14920 | 1/20 | 0.51 |
| ▸ | LIMK2 | P53671 | 1/20 | 0.51 |
| ▸ | F2 | P00734 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6973491 | 0.85 | IKBKB (0.69) | L3MBTL1HTR6CYP19A1MEN1KMT2A | |
| SCHEMBL15232994 | 0.82 | PKM (0.60) | L3MBTL1HTR6CYP19A1MEN1KMT2A | |
| SCHEMBL13028510 | 0.82 | IKBKB (0.64) | L3MBTL1HTR6CYP19A1MEN1KMT2A | |
| SCHEMBL509524 | 0.81 | FFAR1 (0.64) | MEN1KMT2AALDH1A1AR | |
| SCHEMBL6984050 | 0.81 | FFAR1 (0.64) | MEN1KMT2AALDH1A1AR | |
| SCHEMBL3555622 | 0.78 | SLC16A3 (0.72) | HTR6MEN1KMT2AALDH1A1LIMK2 | |
| SCHEMBL3088575 | 0.77 | HTR6 (0.79) | L3MBTL1HTR6CYP19A1MEN1KMT2A | |
| SCHEMBL7175051 | 0.77 | HSD17B2 (0.72) | L3MBTL1CYP19A1MEN1KMT2AALDH1A1 | |
| SCHEMBL13875341 | 0.77 | L3MBTL1 (0.67) | L3MBTL1MEN1KMT2AALDH1A1ESR1 | |
| SCHEMBL3556294 | 0.77 | SLC16A3 (0.61) | HTR6MEN1KMT2AALDH1A1LIMK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1109560-B1 | COMPOUNDS USEFUL AS AICARFT INHIBITORS | AGOURON PHARMA (US) | 2003-08-27 | — | — | EP | disclosed |
| US-6525050-B1 | Inhibit the enzyme aminoimidazole carboxamide ribonucleotide formyl transferase; antiproliferative agents; antitumor, antiinflammatory, antipsoriatic, and/or immunosuppressive | AGOURON PHARMACEUTICALS, INC. | 2003-02-25 | — | — | US | disclosed |
| EP-1109560-A4 | COMPOUNDS USEFUL AS AICARFT INHIBITORS | AGOURON PHARMA (US) | 2002-04-17 | — | — | EP | disclosed |
| EP-1109560-A1 | COMPOUNDS USEFUL AS AICARFT INHIBITORS | AGOURON PHARMACEUTICALS, INC. (US) | 2001-06-27 | — | — | EP | disclosed |
| WO-2000013688-A1 | COMPOUNDS USEFUL AS AICARFT INHIBITORS | AGOURON PHARMACEUTICALS, INC. (US) | 2000-03-16 | — | — | WO | disclosed |