Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR1 | O14842 | 2/20 | 0.64 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.64 |
| ▸ | CA1 | P00915 | 1/20 | 0.63 |
| ▸ | CA2 | P00918 | 1/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.58 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.58 |
| ▸ | POLB | P06746 | 2/20 | 0.56 |
| ▸ | AR | P10275 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 3/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.55 |
| ▸ | MAPT | P10636 | 2/20 | 0.55 |
| ▸ | PKM | P14618 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL509524 | 1.00 | FFAR1 (0.64) | FFAR1FFAR4CA1CA2ALDH1A1 | |
| SCHEMBL7501950 | 0.86 | CA1 (0.81) | FFAR1FFAR4CA1CA2ALDH1A1 | |
| Hydrochloric Acid SCHEMBL5797806 | 0.84 | CA1 (0.79) | FFAR1FFAR4CA1CA2ALDH1A1 | |
| SCHEMBL19234503 | 0.83 | UCHL1 (0.76) | FFAR1FFAR4CA1CA2ALDH1A1 | |
| SCHEMBL6980613 | 0.83 | FFAR1 (0.64) | FFAR1FFAR4CA1CA2ALDH1A1 | |
| SCHEMBL28692275 | 0.83 | KMT2A (0.67) | CA1CA2ALDH1A1ARMEN1 | |
| SCHEMBL6973976 | 0.81 | L3MBTL1 (0.58) | ALDH1A1ARMEN1KMT2A | |
| SCHEMBL3919353 | 0.81 | CA1 (0.69) | FFAR1FFAR4CA1CA2ALDH1A1 | |
| SCHEMBL7507787 | 0.80 | CA1 (0.71) | CA1CA2ALDH1A1CYP2C9POLB | |
| SCHEMBL20715711 | 0.80 | ALDH1A1 (0.68) | FFAR1FFAR4CA1CA2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1109560-B1 | COMPOUNDS USEFUL AS AICARFT INHIBITORS | AGOURON PHARMA (US) | 2003-08-27 | — | — | EP | disclosed |
| US-6525050-B1 | Inhibit the enzyme aminoimidazole carboxamide ribonucleotide formyl transferase; antiproliferative agents; antitumor, antiinflammatory, antipsoriatic, and/or immunosuppressive | AGOURON PHARMACEUTICALS, INC. | 2003-02-25 | — | — | US | disclosed |
| EP-1109560-A4 | COMPOUNDS USEFUL AS AICARFT INHIBITORS | AGOURON PHARMA (US) | 2002-04-17 | — | — | EP | disclosed |
| EP-1109560-A1 | COMPOUNDS USEFUL AS AICARFT INHIBITORS | AGOURON PHARMACEUTICALS, INC. (US) | 2001-06-27 | — | — | EP | disclosed |
| WO-2000013688-A1 | COMPOUNDS USEFUL AS AICARFT INHIBITORS | AGOURON PHARMACEUTICALS, INC. (US) | 2000-03-16 | — | — | WO | disclosed |