Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.32 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.31 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | SYK | P43405 | 1/20 | 0.30 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.30 |
| ▸ | INCENP | Q9NQS7 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6974365 | 0.90 | GRIN1 (0.35) | HRH1SYK | |
| SCHEMBL6960270 | 0.90 | ALDH1A1 (0.36) | HRH1ALDH1A1TP53KDM4E | |
| SCHEMBL7164319 | 0.90 | GRM5 (0.32) | HRH1ALDH1A1TLR7TP53 | |
| SCHEMBL7081701 | 0.90 | S1PR3 (0.34) | HRH1TLR7SYK | |
| SCHEMBL7080025 | 0.88 | CYP1A2 (0.36) | ALDH1A1PTGDR2TP53KDM4ESYK | |
| SCHEMBL6967466 | 0.87 | ALDH1A1 (0.33) | ALDH1A1PTGDR2TLR7TP53KDM4E | |
| SCHEMBL6969925 | 0.87 | CFTR (0.41) | ALDH1A1KDM4E | |
| SCHEMBL7084157 | 0.87 | TLR7 (0.37) | HRH1ALDH1A1ALOX5APPTGDR2TLR7 | |
| SCHEMBL6963974 | 0.87 | ALDH1A1 (0.37) | HRH1ALDH1A1ALOX5APPTGDR2TLR7 | |
| SCHEMBL6967059 | 0.85 | MAPT (0.33) | ALDH1A1ALOX5APTLR7TP53KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0786455-B1 | IMIDAZOLE DERIVATIVE | SHIONOGI & CO (JP) | 2003-12-03 | — | — | EP | disclosed |
| US-6147097-A | METHOD FOR TREATING AIDS | SHIONOGI & CO., LTD. (JP) | 2000-11-14 | — | — | US | disclosed |
| US-5910506-A | IMIDAZOLE DERIVATIVES, E.G.5-(3,5-DICHLOROPHENYLTHIO)-1,2-DIMETHYL-4-ISOPROPYL-1H-IMIDAZOLE; VIRICIDES; AIDS; NONTOXIC | SHIONOGI & CO., LTD. (JP) | 1999-06-08 | — | — | US | disclosed |
| EP-0786455-A1 | IMIDAZOLE DERIVATIVE | SHIONOGI & CO., LTD. (JP) | 1997-07-30 | — | — | EP | disclosed |