SCHEMBL6963974

SCHEMBL6963974

CC(C)c1nc(CO)n(Cc2ccccn2)c1Sc1ccccc1

nearest known ligand 0.37

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 5/20 0.37
HRH1 P35367 2/20 0.35
SMN1; SMN2 Q16637 2/20 0.35
PTGDR2 Q9Y5Y4 1/20 0.35
ALOX5AP P20292 1/20 0.35
TLR7 Q9NYK1 2/20 0.34
TP53 P04637 2/20 0.33
KCNH2 Q12809 1/20 0.33
CYP1A2 P05177 1/20 0.33
CYP2C19 P33261 1/20 0.33
LMNA P02545 2/20 0.32
KDM4E B2RXH2 2/20 0.32
NPC1 O15118 1/20 0.32
RAB9A P51151 1/20 0.32
GAA P10253 1/20 0.32
GABRA1 P14867 1/20 0.32
GABRA5 P31644 1/20 0.32
L3MBTL1 Q9Y468 1/20 0.32
NPSR1 Q6W5P4 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7084157 0.91 TLR7 (0.37) ALDH1A1HRH1SMN1; SMN2PTGDR2ALOX5AP
SCHEMBL7081548 0.89 BRD4 (0.36) HRH1PTGDR2ALOX5APTLR7KDM4E
SCHEMBL7084830 0.89 TLR7 (0.40) ALDH1A1HRH1PTGDR2ALOX5APTLR7
SCHEMBL6967980 0.89 GRIN1 (0.39) ALDH1A1SMN1; SMN2KDM4ERAB9A
SCHEMBL7079929 0.89 GRM5 (0.38) ALDH1A1HRH1SMN1; SMN2TP53CYP1A2
SCHEMBL6965115 0.89 TLR7 (0.36) ALDH1A1HRH1SMN1; SMN2PTGDR2ALOX5AP
SCHEMBL6973511 0.88 S1PR3 (0.36) ALDH1A1HRH1ALOX5APTLR7LMNA
SCHEMBL6976953 0.88 ALDH1A1 (0.33) ALDH1A1HRH1ALOX5APTLR7TP53
SCHEMBL5621516 0.87 GRIN1 (0.39) SMN1; SMN2NPC1RAB9AGAA
SCHEMBL6972789 0.87 HRH3 (0.35) ALDH1A1SMN1; SMN2ALOX5APTLR7TP53

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0786455-B1 IMIDAZOLE DERIVATIVE SHIONOGI & CO (JP) 2003-12-03 EP disclosed
US-6147097-A METHOD FOR TREATING AIDS SHIONOGI & CO., LTD. (JP) 2000-11-14 US disclosed
US-5910506-A IMIDAZOLE DERIVATIVES, E.G.5-(3,5-DICHLOROPHENYLTHIO)-1,2-DIMETHYL-4-ISOPROPYL-1H-IMIDAZOLE; VIRICIDES; AIDS; NONTOXIC SHIONOGI & CO., LTD. (JP) 1999-06-08 US disclosed
EP-0786455-A1 IMIDAZOLE DERIVATIVE SHIONOGI & CO., LTD. (JP) 1997-07-30 EP disclosed