SCHEMBL6974773

SCHEMBL6974773

CC1C(=O)c2ccccc2N1C

nearest known ligand 0.60

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GPR3 P46089 1/20 0.60
KDM4E B2RXH2 7/20 0.47
ALDH1A1 P00352 7/20 0.47
HPGD P15428 4/20 0.47
CES1 P23141 2/20 0.44
TTR P02766 1/20 0.44
GAA P10253 2/20 0.44
PTPN2 P17706 1/20 0.43
PTPN1 P18031 1/20 0.43
HSD17B10 Q99714 3/20 0.42
CASP1 P29466 2/20 0.42
BCHE P06276 1/20 0.38
TGM2 P21980 1/20 0.38
ACHE P22303 1/20 0.38
LMNA P02545 2/20 0.38
GLA P06280 2/20 0.38
MAPT P10636 1/20 0.38
HTT P42858 1/20 0.38
CACNA1B Q00975 1/20 0.38
APBA1 Q02410 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL27740780 0.98 GPR3 (0.58) GPR3KDM4EALDH1A1HPGDCES1
SCHEMBL19854406 0.81 ALDH1A1 (0.49) GPR3KDM4EALDH1A1HPGDCES1
SCHEMBL29219073 0.80 GPR3 (0.47) GPR3KDM4EALDH1A1HPGDCES1
SCHEMBL19508807 0.79 CASP3 (0.45) GPR3KDM4EALDH1A1HPGDCES1
SCHEMBL68922 0.78 KDM4E (0.46) GPR3KDM4EALDH1A1HPGDCES1
SCHEMBL18648461 0.78 KDM4E (0.46) GPR3KDM4EALDH1A1HPGDCES1
SCHEMBL11292294 0.78 KDM4E (0.42) GPR3KDM4EALDH1A1HPGDCES1
SCHEMBL5804657 0.78 KDM4E (0.46) GPR3KDM4EALDH1A1HPGDCES1
SCHEMBL9377925 0.75 GPR3 (1.00) GPR3KDM4EALDH1A1HPGDCES1
SCHEMBL22548875 0.75 ALDH1A1 (0.40) GPR3KDM4EALDH1A1HPGDCES1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 43 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-109743875-A The inhibitor of MENIN-MLL interaction 生命医药公司 2019-05-10 CN claimed
EP-3010914-A1 INDOLIN-2-ONE OR PYRROLO-PYRIDIN/PYRIMIDIN-2-ONE DERIVATIVES F. Hoffmann-La Roche AG (CH) 2016-04-27 EP claimed
WO-2014202493-A1 INDOLIN-2-ONE OR PYRROLO-PYRIDIN/PYRIMIDIN-2-ONE DERIVATIVES F. HOFFMANN-LA ROCHE AG (CH) 2014-12-24 WO claimed
EP-4291193-A1 EGFR DEGRADERS AND METHODS OF USE BeiGene Switzerland GmbH (CH) 2023-12-20 EP disclosed
WO-2023236920-A1 SARM1 MODULATORS, PREPARATIONS, AND USES THEREOF Sironax Ltd. (KY) 2023-12-14 WO disclosed
WO-2023125907-A1 DEGRADATION OF BRUTON'S TYROSINE KINASE (BTK) BY CONJUGATION OF BTK INHIBITORS WITH E3 LIGASE LIGAND AND METHODS OF USE BEIGENE, LTD. (KY) 2023-07-06 WO disclosed
EP-3947369-A1 HETEROCYCLIC COMPOUNDS AS BCR-ABL INHIBITORS Ascentage Pharma (Suzhou) Co., Ltd. (CN) 2022-02-09 EP disclosed
WO-2022012623-A1 DEGRADATION OF (EGFR) BY CONJUGATION OF EGFR INHIBITORS WITH E3 LIGASE LIGAND AND METHODS OF USE BEIGENE, LTD. (KY) 2022-01-20 WO disclosed
WO-2022012622-A1 DEGRADATION OF (EGFR) BY CONJUGATION OF EGFR INHIBITORS WITH E3 LIGASE LIGAND AND METHODS OF USE BEIGENE, LTD. (KY) 2022-01-20 WO disclosed
WO-2021018194-A1 HETEROCYCLIC COMPOUNDS AS BCR-ABL INHIBITORS ASCENTAGE PHARMA (SUZHOU) CO., LTD. (CN) 2021-02-04 WO disclosed
CN-106459029-B Indolin-2-one or pyrrolo-pyridine -2- ketone derivatives 豪夫迈·罗氏有限公司 2019-10-25 CN disclosed
CN-1953976-A Pyrimidine derivatives for use as vanilloid receptor ligands and their use in the treatment of pain AMGEN INC (US) 2007-04-25 CN disclosed
CN-1143847-C Thio-oxindole derivatives �Ʒ� 2004-03-31 CN disclosed
EP-1341759-A2 3-SUBSTITUTED OXINDOLE BETA 3 AGONISTS ELI LILLY AND COMPANY (US) 2003-09-10 EP disclosed
WO-2002038543-A2 3-SUBSTITUTED OXINDOLE BETA 3 AGONISTS ELI LILLY AND COMPANY (US) 2002-05-16 WO disclosed
WO-2002038544-A2 3-SUBSTITUTED OXINDOLE BETA 3 AGONISTS ELI LILLY AND COMPANY (US) 2002-05-16 WO disclosed
CN-1349499-A Thio-oxindole derivatives AMERICAN HOME PROD (US) 2002-05-15 CN disclosed
WO-1999058525-A1 INDOLE DERIVATIVES AS 5-HT2A LIGANDS AND AS SEROTONINE REUPTAKE INHIBITORS ELI LILLY AND COMPANY LIMITED (GB) 1999-11-18 WO disclosed
CN-85103724-B Process for preparing pyrrolobenzimidazoles 曼海姆伯灵格股份公司 1988-07-06 CN disclosed
CN-85103724-A The method for preparing novel pyrrolo-benzoglyoxaline 1986-07-02 CN disclosed