Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC4 | P56524 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 3/20 | 0.38 |
| ▸ | RAB9A | P51151 | 3/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.37 |
| ▸ | TSHR | P16473 | 3/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.37 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.35 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | DPP4 | P27487 | 1/20 | 0.33 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8602514 | 0.84 | HDAC4 (0.41) | HDAC4NPC1RAB9AL3MBTL1TSHR | |
| SCHEMBL8554106 | 0.78 | L3MBTL1 (0.56) | CA1CA2NPC1RAB9AL3MBTL1 | |
| SCHEMBL21332420 | 0.75 | NPC1 (0.58) | HDAC4NPC1RAB9AL3MBTL1TSHR | |
| SCHEMBL5098195 | 0.74 | NR1I2 (0.52) | HDAC4 | |
| SCHEMBL8824551 | 0.74 | TP53 (0.37) | HDAC4NPC1RAB9AL3MBTL1TSHR | |
| SCHEMBL8875104 | 0.71 | RAB9A (0.54) | CA1CA2NPC1RAB9AL3MBTL1 | |
| SCHEMBL14070535 | 0.70 | CA1 (0.65) | CA1CA2NPC1RAB9AL3MBTL1 | |
| SCHEMBL8977892 | 0.69 | L3MBTL1 (0.50) | CA1CA2NPC1RAB9AL3MBTL1 | |
| SCHEMBL21332316 | 0.68 | HDAC4 (0.43) | HDAC4NPC1RAB9AS1PR1SMN1; SMN2 | |
| SCHEMBL28761225 | 0.68 | HDAC4 (0.41) | HDAC4NPC1RAB9AL3MBTL1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0759755-B1 | Thiadiazolylalkoxyphenyl derivatives, their preparation and their use anti-picornaviral agents | SANOFI SYNTHELABO (FR) | 2003-08-13 | — | — | EP | disclosed |
| CN-1095664-C | Thiadiazoles and their use as antipicornaviral agent | SANNOFFE SYNTHELAB S A (FR) | 2002-12-11 | — | — | CN | disclosed |
| US-5821257-A | Thiadiazoles and their uses as antipicornaviral agents | SANOFI (FR) | 1998-10-13 | — | — | US | disclosed |
| US-5750527-A | VIRICIDES | SANOFI (FR) | 1998-05-12 | — | — | US | disclosed |
| US-5721261-A | TREATING PICORNAVIRUS INFECTIONS | SANOFI PHARMACEUTICALS, INC. (US) | 1998-02-24 | — | — | US | disclosed |
| US-5665763-A | ANTIPICORNAVIRAL AGENTS | SANOFI, S.A. (FR) | 1997-09-09 | — | — | US | disclosed |
| US-5650419-A | Thiadiazoles and their use as antipicornaviral agents | SANOFI, S.A. | 1997-07-22 | — | — | US | disclosed |
| CN-1148339-A | Thiadiazoles and their use as antipicornaviral agent | SANOFI WINTHROP INC (US) | 1997-04-23 | — | — | CN | disclosed |
| US-5567717-A | COMBATTING PICORNAVIRUSES | STERLING WINTHROP, INC. (US) | 1996-10-22 | — | — | US | disclosed |
| US-5567719-A | Thiadiazoles and their use as antipicornaviral agents | STERLING WINTHROP, INC. (US) | 1996-10-22 | — | — | US | disclosed |
| US-5514679-A | TREATMENT OF PICORNAVIRUS INFECTIONS | STERLING WINTHROP INC. (US) | 1996-05-07 | — | — | US | disclosed |
| WO-1995031439-A1 | THERAPEUTIC PHENOXYALKYLPYRIDAZINES AND INTERMEDIATES THEREFOR | SANOFI WINTHROP, INC. (US) | 1995-11-23 | — | — | WO | disclosed |
| US-5453433-A | Viricides; antiseptics to decontaminate polio, rhino and coxsackie viruses | STERLING WINTHROP INC. (US) | 1995-09-26 | — | — | US | disclosed |