Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 6/20 | 0.48 |
| ▸ | MAPT | P10636 | 4/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | TSHR | P16473 | 3/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | ELANE | P08246 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.38 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.38 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.37 |
| ▸ | HTR3A | P46098 | 1/20 | 0.37 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.37 |
| ▸ | PTGES | O14684 | 3/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7084682 | 0.84 | LMNA (0.45) | LMNAMAPTSMN1; SMN2TSHRHTT | |
| SCHEMBL6966984 | 0.82 | LMNA (0.50) | LMNAMAPTSMN1; SMN2TSHRHTT | |
| SCHEMBL6972076 | 0.82 | LMNA (0.52) | LMNAMAPTSMN1; SMN2TSHRHTT | |
| SCHEMBL6975929 | 0.82 | LMNA (0.52) | LMNAMAPTSMN1; SMN2TSHRHTT | |
| SCHEMBL6975288 | 0.81 | LMNA (0.48) | LMNAMAPTSMN1; SMN2TSHRHTT | |
| SCHEMBL6974109 | 0.80 | LMNA (0.53) | LMNAMAPTSMN1; SMN2TSHRHTT | |
| SCHEMBL7680423 | 0.80 | LMNA (0.58) | LMNAMAPTSMN1; SMN2TSHRHTT | |
| SCHEMBL6978779 | 0.79 | OPRK1 (0.56) | LMNAMAPTSMN1; SMN2TSHRHTT | |
| SCHEMBL6968264 | 0.79 | OPRK1 (0.56) | LMNAMAPTSMN1; SMN2TSHRHTT | |
| SCHEMBL7846258 | 0.79 | LMNA (0.59) | LMNAMAPTSMN1; SMN2TSHRHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6562964-B1 | Inhibitors of rotamase enzymes in particular FKBP-12 and FKBP-52. The compounds therefore moderate neuronal regeneration and outgrowth and can be used for treating neurological disorders arising from neurodegenerative diseases or other disorders | PFIZER INC | 2003-05-13 | — | — | US | disclosed |
| EP-1100797-B1 | HETEROCYCLIC COMPOUNDS AS INHIBITORS OF ROTAMASE ENZYMES | PFIZER LTD (GB) | 2003-02-26 | — | — | EP | disclosed |
| US-6372736-B1 | ENZYME INHIBITORS | PFIZER INC | 2002-04-16 | — | — | US | disclosed |