Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 5/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.52 |
| ▸ | MAPT | P10636 | 3/20 | 0.52 |
| ▸ | HTT | P42858 | 3/20 | 0.52 |
| ▸ | TSHR | P16473 | 3/20 | 0.52 |
| ▸ | ELANE | P08246 | 2/20 | 0.43 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.41 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | CNR1 | P21554 | 2/20 | 0.40 |
| ▸ | CNR2 | P34972 | 2/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.40 |
| ▸ | HTR3A | P46098 | 1/20 | 0.40 |
| ▸ | PTGES | O14684 | 3/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6972076 | 1.00 | LMNA (0.52) | LMNASMN1; SMN2MAPTHTTTSHR | |
| SCHEMBL6974109 | 0.83 | LMNA (0.53) | LMNASMN1; SMN2MAPTHTTTSHR | |
| SCHEMBL7680423 | 0.83 | LMNA (0.58) | LMNASMN1; SMN2MAPTHTTTSHR | |
| SCHEMBL6975277 | 0.82 | LMNA (0.48) | LMNASMN1; SMN2MAPTHTTTSHR | |
| SCHEMBL7846258 | 0.82 | LMNA (0.59) | LMNASMN1; SMN2MAPTHTTTSHR | |
| SCHEMBL6979378 | 0.82 | LMNA (0.59) | LMNASMN1; SMN2MAPTHTTTSHR | |
| SCHEMBL6970992 | 0.80 | LMNA (0.54) | LMNASMN1; SMN2MAPTHTTTSHR | |
| SCHEMBL6976210 | 0.80 | LMNA (0.54) | LMNASMN1; SMN2MAPTHTTTSHR | |
| SCHEMBL6968264 | 0.80 | OPRK1 (0.56) | LMNASMN1; SMN2MAPTHTTTSHR | |
| SCHEMBL6978779 | 0.80 | OPRK1 (0.56) | LMNASMN1; SMN2MAPTHTTTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1100797-B1 | HETEROCYCLIC COMPOUNDS AS INHIBITORS OF ROTAMASE ENZYMES | PFIZER LTD (GB) | 2003-02-26 | — | — | EP | disclosed |