Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | MAPT | P10636 | 4/20 | 0.48 |
| ▸ | DRD2 | P14416 | 5/20 | 0.46 |
| ▸ | DRD3 | P35462 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | HTR2A | P28223 | 3/20 | 0.45 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.44 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.44 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 3/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | GLA | P06280 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6977707 | 0.80 | MAPT (0.62) | ALDH1A1MAPTDRD2LMNAKDM4E | |
| SCHEMBL1397389 | 0.77 | DRD2 (0.60) | ALDH1A1MAPTDRD2DRD3LMNA | |
| SCHEMBL14320628 | 0.77 | MAPT (0.59) | ALDH1A1MAPTDRD2DRD3LMNA | |
| Hydrochloric Acid SCHEMBL6343779 | 0.76 | KDM4E (0.59) | ALDH1A1MAPTDRD2DRD3LMNA | |
| Hydrochloric Acid SCHEMBL6345252 | 0.76 | KDM4E (0.59) | ALDH1A1MAPTDRD2DRD3LMNA | |
| SCHEMBL6980846 | 0.75 | ALDH1A1 (0.44) | ALDH1A1MAPTDRD2DRD3LMNA | |
| SCHEMBL5701472 | 0.75 | ALDH1A1 (0.57) | ALDH1A1MAPTLMNAKDM4EGAA | |
| SCHEMBL6355490 | 0.75 | ALDH1A1 (0.60) | ALDH1A1MAPTDRD2LMNAKDM4E | |
| SCHEMBL6975327 | 0.74 | MEN1 (0.62) | ALDH1A1MAPTDRD2LMNAKDM4E | |
| SCHEMBL8984896 | 0.74 | ALDH1A1 (0.53) | ALDH1A1MAPTLMNAKDM4EGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0946539-B1 | SULPHONAMIDE DERIVATIVES, PROCESS FOR THEIR PREPARATION, AND THEIR USE AS MEDICAMENTS | SMITHKLINE BEECHAM PLC (GB) | 2003-08-13 | — | — | EP | disclosed |
| US-6599904-B2 | 5-HT6 receptor antagonists are believed to be of potential use in the treatment of certain CNS disorders; cognitive memory enhancement | SMITHKLINE BEECHAM P.L.C. (GB) | 2003-07-29 | — | — | US | disclosed |