Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.62 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.62 |
| ▸ | LMNA | P02545 | 4/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.62 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | NPC1 | O15118 | 1/20 | 0.54 |
| ▸ | CASP3 | P42574 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.54 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.51 |
| ▸ | SLC6A5 | Q9Y345 | 1/20 | 0.50 |
| ▸ | HTR1A | P08908 | 3/20 | 0.48 |
| ▸ | DRD2 | P14416 | 1/20 | 0.48 |
| ▸ | HTR2A | P28223 | 1/20 | 0.48 |
| ▸ | HTR6 | P50406 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2389164 | 0.82 | ALDH1A1 (0.53) | MAPTALDH1A1MAPK1LMNASMN1; SMN2 | |
| SCHEMBL1846738 | 0.81 | ALDH1A1 (0.57) | MAPTALDH1A1MAPK1LMNASMN1; SMN2 | |
| SCHEMBL4865184 | 0.81 | HTR6 (0.62) | MAPTALDH1A1MAPK1LMNASMN1; SMN2 | |
| SCHEMBL2390332 | 0.80 | ALDH1A1 (0.68) | MAPTALDH1A1MAPK1LMNASMN1; SMN2 | |
| SCHEMBL6975324 | 0.80 | ALDH1A1 (0.48) | MAPTALDH1A1MAPK1LMNASMN1; SMN2 | |
| SCHEMBL1849303 | 0.80 | TDP1 (0.61) | MAPTALDH1A1MAPK1LMNASMN1; SMN2 | |
| SCHEMBL2390066 | 0.79 | ALDH1A1 (0.60) | MAPTALDH1A1MAPK1LMNASMN1; SMN2 | |
| SCHEMBL21644501 | 0.78 | ALDH1A1 (0.54) | MAPTALDH1A1MAPK1LMNASMN1; SMN2 | |
| SCHEMBL283237 | 0.77 | ALDH1A1 (0.60) | MAPTALDH1A1MAPK1LMNASMN1; SMN2 | |
| SCHEMBL520263 | 0.77 | SLC6A5 (0.61) | MAPTALDH1A1MAPK1LMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0946539-B1 | SULPHONAMIDE DERIVATIVES, PROCESS FOR THEIR PREPARATION, AND THEIR USE AS MEDICAMENTS | SMITHKLINE BEECHAM PLC (GB) | 2003-08-13 | — | — | EP | disclosed |
| US-6599904-B2 | 5-HT6 receptor antagonists are believed to be of potential use in the treatment of certain CNS disorders; cognitive memory enhancement | SMITHKLINE BEECHAM P.L.C. (GB) | 2003-07-29 | — | — | US | disclosed |
| US-6423717-B1 | NERVOUS SYSTEM DISORDERS | SMITHKLINE BEECHAM P.L.C. (GB) | 2002-07-23 | — | — | US | disclosed |