Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 4/20 | 0.44 |
| ▸ | CNR2 | P34972 | 8/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | GRM1 | Q13255 | 3/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | GRM5 | P41594 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6973729 | 0.84 | ALDH1A1 (0.40) | HSD11B1ALDH1A1TSHRKDM4ELMNA | |
| SCHEMBL3873900 | 0.79 | SIRT1 (0.40) | TSHRSMN1; SMN2 | |
| SCHEMBL6974045 | 0.79 | KCNH2 (0.32) | GRM1 | |
| SCHEMBL4503987 | 0.77 | F11 (0.40) | ALDH1A1TSHRKDM4ESMN1; SMN2NPSR1 | |
| SCHEMBL6962545 | 0.76 | MEN1 (0.41) | LMNA | |
| SCHEMBL6962527 | 0.76 | ACE (0.40) | — | |
| SCHEMBL6973111 | 0.76 | MEN1 (0.43) | HSD11B1CNR2ALDH1A1TSHRLMNA | |
| SCHEMBL6960911 | 0.76 | ACE (0.36) | — | |
| SCHEMBL6967292 | 0.75 | KEAP1 (0.38) | ALDH1A1TSHRHTTLMNASMN1; SMN2 | |
| SCHEMBL6972820 | 0.75 | MEN1 (0.41) | HSD11B1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0832069-B1 | BIPHENYL-2-CARBOXYLIC ACID-TETRAHYDRO-ISOQUINOLIN-6-YL AMIDE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS INHIBITORS OF MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN AND/OR APOLIPOPROTEIN B (Apo B) SECRETION | PFIZER (US) | 2003-03-05 | — | — | EP | disclosed |
| EP-1181954-A2 | Biphenyl-2-carboxylic acid-tetrahydro-isoquinolin-6-yl amide derivatives, their preparation and use as inhibitors of microsomal triglyceride transfer protein and/or apolipoprotein B (ApoB) secretion | PFIZER INC. (US) | 2002-02-27 | — | — | EP | disclosed |