Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNMT | P11086 | 5/20 | 0.38 |
| ▸ | SLC6A9 | P48067 | 9/20 | 0.35 |
| ▸ | GFER | P55789 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.33 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.33 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.33 |
| ▸ | SLC6A5 | Q9Y345 | 2/20 | 0.33 |
| ▸ | KDM1A | O60341 | 1/20 | 0.32 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.32 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.32 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.32 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.32 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.32 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6490566 | 0.89 | PNMT (0.38) | PNMTSLC6A9KCNH2TMEM97SIGMAR1 | |
| SCHEMBL6492438 | 0.76 | BRD4 (0.38) | PNMT | |
| SCHEMBL8317800 | 0.71 | RYR2 (0.42) | — | |
| SCHEMBL8318662 | 0.70 | DPP8 (0.36) | KCNH2TMEM97SIGMAR1 | |
| SCHEMBL6982495 | 0.68 | KCNH2 (0.32) | PNMTSLC6A9KCNH2TMEM97SIGMAR1 | |
| SCHEMBL6500053 | 0.65 | KCNH2 (0.32) | PNMTSLC6A9KCNH2TMEM97SIGMAR1 | |
| SCHEMBL6527029 | 0.65 | BRD4 (0.33) | PNMTSLC6A9KCNH2TMEM97SIGMAR1 | |
| SCHEMBL6527031 | 0.65 | ALDH1A1 (0.38) | SLC6A9KCNH2TMEM97SIGMAR1 | |
| SCHEMBL8315757 | 0.63 | CA12 (0.36) | KCNH2TMEM97SIGMAR1 | |
| SCHEMBL6527027 | 0.63 | KCNH2 (0.34) | PNMTSLC6A9KCNH2TMEM97SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1131321-B1 | INDOLE DERIVATIVES AND THEIR USE AS SEROTONIN RECEPTOR LIGANDS | LILLY CO ELI (GB) | 2003-09-10 | — | — | EP | disclosed |
| US-6329366-B1 | HETEROCYCLIC, PIPERIDINE, INDOLE DERIVITIVES FOR TREATMENT OF NERVOUS SYSTEM DISORDERS AND SEROTONIN ANTAGONIST | ELI LILLY AND COMPANY LIMITED (GB) | 2001-12-11 | — | — | US | disclosed |