Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 4/20 | 0.32 |
| ▸ | TMEM97 | Q5BJF2 | 4/20 | 0.32 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.32 |
| ▸ | PRMT5 | O14744 | 2/20 | 0.31 |
| ▸ | WDR77 | Q9BQA1 | 2/20 | 0.31 |
| ▸ | PNMT | P11086 | 4/20 | 0.31 |
| ▸ | SLC6A9 | P48067 | 2/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | SLC6A5 | Q9Y345 | 1/20 | 0.30 |
| ▸ | XIAP | P98170 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6500053 | 0.91 | KCNH2 (0.32) | KCNH2TMEM97SIGMAR1PRMT5WDR77 | |
| SCHEMBL8316061 | 0.82 | CRY1 (0.35) | KCNH2TMEM97SIGMAR1 | |
| SCHEMBL6984303 | 0.81 | BRD4 (0.32) | PNMTMEN1 | |
| SCHEMBL6985168 | 0.80 | HTR2A (0.40) | — | |
| SCHEMBL8318057 | 0.80 | KDM4E (0.39) | — | |
| SCHEMBL6527029 | 0.74 | BRD4 (0.33) | KCNH2TMEM97SIGMAR1PRMT5WDR77 | |
| SCHEMBL7081764 | 0.74 | — | — | |
| SCHEMBL8316696 | 0.72 | SLC6A2 (0.38) | — | |
| SCHEMBL6984197 | 0.71 | KDM4E (0.41) | PRMT5WDR77MEN1 | |
| SCHEMBL8317987 | 0.71 | ADRA2A (0.36) | KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1131321-B1 | INDOLE DERIVATIVES AND THEIR USE AS SEROTONIN RECEPTOR LIGANDS | LILLY CO ELI (GB) | 2003-09-10 | — | — | EP | disclosed |
| US-6329366-B1 | HETEROCYCLIC, PIPERIDINE, INDOLE DERIVITIVES FOR TREATMENT OF NERVOUS SYSTEM DISORDERS AND SEROTONIN ANTAGONIST | ELI LILLY AND COMPANY LIMITED (GB) | 2001-12-11 | — | — | US | disclosed |