Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAF1 | P04049 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | PPARA | Q07869 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.39 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.39 |
| ▸ | PPARG | P37231 | 3/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6984071 | 0.90 | PPARG (0.45) | RAF1KMT2APPARGMAPK1MEN1 | |
| SCHEMBL6973706 | 0.87 | RAB9A (0.44) | KMT2ALMNARAB9APPARGMAPK1 | |
| SCHEMBL6978533 | 0.87 | MEN1 (0.46) | KMT2ALMNAPPARARAB9APPARG | |
| SCHEMBL6973224 | 0.85 | PPARA (0.43) | KMT2ALMNANPSR1PPARAKEAP1 | |
| SCHEMBL6978109 | 0.84 | PPARG (0.41) | KMT2ALMNAPPARAKEAP1NFE2L2 | |
| SCHEMBL25494271 | 0.78 | MEN1 (0.45) | KMT2ALMNANPSR1RAB9AMAPK1 | |
| SCHEMBL6983841 | 0.77 | LMNA (0.38) | RAF1KMT2ALMNANPSR1PPARA | |
| SCHEMBL6979803 | 0.77 | PPARG (0.45) | KMT2APPARAKEAP1NFE2L2PPARG | |
| SCHEMBL6981268 | 0.75 | RAF1 (0.43) | RAF1KMT2APPARARAB9APPARG | |
| SCHEMBL6982722 | 0.73 | KEAP1 (0.45) | PPARARAB9AKEAP1NFE2L2PPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1030835-B1 | UREA DERIVATIVES AND THEIR USE AS INTEGRIN INHIBITORS | ASTRAZENECA UK LTD (GB) | 2003-01-22 | — | — | EP | disclosed |
| US-6344570-B1 | ANTISTICKING AGENTS FOR CELLS | ASTRAZENECA UK LIMITED (GB) | 2002-02-05 | — | — | US | disclosed |
| EP-1030835-A2 | UREA DERIVATIVES AND THEIR USE AS INTEGRIN INHIBITORS | AstraZeneca UK Limited (GB) | 2000-08-30 | — | — | EP | disclosed |
| WO-1999024398-A2 | UREA DERIVATIVES AND THEIR USE AS INTEGRIN INHIBITORS | ASTRAZENECA UK LIMITED (GB) | 1999-05-20 | — | — | WO | disclosed |