Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | F2RL3 | Q96RI0 | 1/20 | 0.47 |
| ▸ | MAT2A | P31153 | 1/20 | 0.42 |
| ▸ | CNR1 | P21554 | 1/20 | 0.40 |
| ▸ | CAMK2D | Q13557 | 7/20 | 0.40 |
| ▸ | PIM1 | P11309 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | BLM | P54132 | 1/20 | 0.40 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.38 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.38 |
| ▸ | CDK2 | P24941 | 1/20 | 0.38 |
| ▸ | CDK9 | P50750 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.37 |
| ▸ | MPI | P34949 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acetic Acid SCHEMBL7679495 | 0.98 | F2RL3 (0.47) | SMN1; SMN2NPC1GAAF2RL3MAT2A | |
| SCHEMBL6975872 | 0.87 | CNR1 (0.44) | F2RL3CNR1CAMK2DPIM1CCNT1 | |
| SCHEMBL6981835 | 0.85 | CAMK2D (0.43) | CAMK2DPIM1CCNT1CCNA2CDK2 | |
| SCHEMBL6977088 | 0.83 | CAMK2D (0.43) | CAMK2DPIM1CCNT1CCNA2CDK2 | |
| SCHEMBL7671215 | 0.83 | CAMK2D (0.49) | CAMK2DPIM1CCNT1CCNA2CDK2 | |
| Trifluoroacetic Acid SCHEMBL6978549 | 0.82 | GSK3B (0.39) | CAMK2DPIM1CCNT1CCNA2CDK2 | |
| Trifluoroacetic Acid SCHEMBL6983727 | 0.81 | CAMK2D (0.44) | CAMK2DPIM1CCNT1CCNA2CDK2 | |
| Trifluoroacetic Acid SCHEMBL6980387 | 0.81 | CAMK2D (0.39) | CNR1CAMK2DPIM1CCNT1CCNA2 | |
| SCHEMBL6980479 | 0.79 | CAMK2D (0.45) | CAMK2DPIM1CCNT1CCNA2CDK2 | |
| SCHEMBL6975973 | 0.78 | CAMK2D (0.53) | CAMK2DPIM1CCNT1CCNA2CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1095039-B1 | NEW PHARMACEUTICALLY ACTIVE COMPOUNDS | ASTRAZENECA AB (SE) | 2003-08-27 | — | — | EP | claimed |
| US-6346625-B1 | ENZYME INHIBITORS FOR PROTEIN KINASES | ASTRAZENECA AB (SE) | 2002-02-12 | — | — | US | claimed |
| EP-1095039-A2 | NEW PHARMACEUTICALLY ACTIVE COMPOUNDS | AstraZeneca AB (SE) | 2001-05-02 | — | — | EP | claimed |
| WO-2000002877-A2 | NEW PHARMACEUTICALLY ACTIVE COMPOUNDS | ASTRAZENECA AB (SE) | 2000-01-20 | — | — | WO | claimed |
| EP-1095039-B1 | NEW PHARMACEUTICALLY ACTIVE COMPOUNDS | ASTRAZENECA AB (SE) | 2003-08-27 | — | — | EP | disclosed |
| US-6346625-B1 | ENZYME INHIBITORS FOR PROTEIN KINASES | ASTRAZENECA AB (SE) | 2002-02-12 | — | — | US | disclosed |
| EP-1095039-A2 | NEW PHARMACEUTICALLY ACTIVE COMPOUNDS | AstraZeneca AB (SE) | 2001-05-02 | — | — | EP | disclosed |
| WO-2000002877-A2 | NEW PHARMACEUTICALLY ACTIVE COMPOUNDS | ASTRAZENECA AB (SE) | 2000-01-20 | — | — | WO | disclosed |