Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CAMK2D | Q13557 | 11/20 | 0.44 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.37 |
| ▸ | IGF1R | P08069 | 1/20 | 0.37 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.37 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.37 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.37 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.37 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.37 |
| ▸ | CDK2 | P24941 | 1/20 | 0.37 |
| ▸ | CDK9 | P50750 | 1/20 | 0.37 |
| ▸ | PIM1 | P11309 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | PRKACA | P17612 | 1/20 | 0.35 |
| ▸ | PRKACG | P22612 | 1/20 | 0.35 |
| ▸ | PRKACB | P22694 | 1/20 | 0.35 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7671215 | 0.93 | CAMK2D (0.49) | CAMK2DNTRK1IGF1RFGFR1NTRK3 | |
| Trifluoroacetic Acid SCHEMBL6978549 | 0.93 | GSK3B (0.39) | CAMK2DCCNT1CCNA2CDK2CDK9 | |
| Trifluoroacetic Acid SCHEMBL6980387 | 0.89 | CAMK2D (0.39) | CAMK2DCCNT1CCNA2CDK2CDK9 | |
| SCHEMBL6981835 | 0.85 | CAMK2D (0.43) | CAMK2DCCNT1CCNA2CDK2CDK9 | |
| Trifluoroacetic Acid SCHEMBL6982808 | 0.84 | CAMK2D (0.46) | CAMK2DCCNT1CCNA2CDK2CDK9 | |
| Trifluoroacetic Acid SCHEMBL6985258 | 0.83 | CAMK2D (0.39) | CAMK2DCCNT1CCNA2CDK2CDK9 | |
| Trifluoroacetic Acid SCHEMBL6984540 | 0.82 | CAMK2D (0.46) | CAMK2DCCNT1CCNA2CDK2CDK9 | |
| Trifluoroacetic Acid SCHEMBL6981679 | 0.82 | GSK3B (0.38) | CAMK2DCCNT1CCNA2CDK2CDK9 | |
| SCHEMBL6977088 | 0.81 | CAMK2D (0.43) | CAMK2DCCNT1CCNA2CDK2CDK9 | |
| Trifluoroacetic Acid SCHEMBL6977475 | 0.81 | CAMK2D (0.48) | CAMK2DCCNT1CCNA2CDK2CDK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1095039-B1 | NEW PHARMACEUTICALLY ACTIVE COMPOUNDS | ASTRAZENECA AB (SE) | 2003-08-27 | — | — | EP | disclosed |
| US-6346625-B1 | ENZYME INHIBITORS FOR PROTEIN KINASES | ASTRAZENECA AB (SE) | 2002-02-12 | — | — | US | disclosed |
| EP-1095039-A2 | NEW PHARMACEUTICALLY ACTIVE COMPOUNDS | AstraZeneca AB (SE) | 2001-05-02 | — | — | EP | disclosed |
| WO-2000002877-A2 | NEW PHARMACEUTICALLY ACTIVE COMPOUNDS | ASTRAZENECA AB (SE) | 2000-01-20 | — | — | WO | disclosed |