Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 4/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.43 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | PTGES | O14684 | 1/20 | 0.42 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6977607 | 0.89 | KCNH2 (0.40) | NPC1RAB9AL3MBTL1MEN1KMT2A | |
| SCHEMBL6963364 | 0.85 | MEN1 (0.54) | MEN1KMT2ASMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL6970855 | 0.85 | KCNA5 (0.53) | NPC1RAB9AMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL6975974 | 0.83 | AKR1C3 (0.48) | RAB9AL3MBTL1MEN1KMT2AMAPT | |
| SCHEMBL6969760 | 0.80 | AKR1C3 (0.39) | MEN1KMT2AMAPTALDH1A1AKR1C3 | |
| SCHEMBL6967437 | 0.80 | KMT2A (0.43) | MEN1KMT2AMAPTALDH1A1GAA | |
| SCHEMBL6975027 | 0.80 | HTR6 (0.45) | MEN1KMT2AMAPTALDH1A1AKR1C3 | |
| SCHEMBL6969751 | 0.79 | SGMS1 (0.47) | NPC1L3MBTL1KMT2AALDH1A1CYP2C19 | |
| SCHEMBL6965033 | 0.79 | AKR1C3 (0.44) | RAB9AMEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL6968051 | 0.78 | AKR1C3 (0.46) | ALDH1A1GAAAKR1C3AKR1C2PTGES |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1077947-B1 | NOVEL 1,5 AND 3-O-SUBSTITUTED 1H-INDAZOLES WITH ANTI-ASTHMATIC, ANTI-ALLERGIC, ANTI-INFLAMMATORY, IMMUNO-MODULATING AND NEURO-PROTECTIVE EFFECT, METHOD FOR THE PRODUCTION AND USE THEREOF AS MEDICAMENTS | DRESDEN ARZNEIMITTEL (DE) | 2003-09-03 | — | — | EP | claimed |