Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 3/20 | 0.59 |
| ▸ | NPC1 | O15118 | 1/20 | 0.59 |
| ▸ | RECQL | P46063 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.36 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.35 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14028404 | 0.75 | RAB9A (1.00) | RAB9ANPC1RECQLALDH1A1LMNA | |
| SCHEMBL10288448 | 0.72 | CYP2C19 (0.44) | RAB9ANPC1RECQLALDH1A1LMNA | |
| SCHEMBL6969631 | 0.70 | HSD11B1 (0.44) | ALDH1A1MAPTKMT2AMEN1KDM4E | |
| SCHEMBL13059104 | 0.70 | — | — | |
| SCHEMBL6778626 | 0.68 | ALDH1A1 (0.40) | RAB9ANPC1RECQLALDH1A1LMNA | |
| SCHEMBL14012156 | 0.68 | ALDH1A1 (0.40) | RAB9ANPC1RECQLALDH1A1LMNA | |
| SCHEMBL8126668 | 0.68 | MAPK1 (0.54) | RAB9ANPC1RECQLALDH1A1LMNA | |
| SCHEMBL27553901 | 0.67 | ALDH1A1 (0.39) | RAB9ANPC1ALDH1A1KMT2AMEN1 | |
| SCHEMBL14037790 | 0.65 | CYP2C19 (0.38) | RAB9ANPC1RECQLALDH1A1LMNA | |
| SCHEMBL8992959 | 0.65 | IDO1 (0.46) | ALDH1A1LMNAMAPTKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6566376-B1 | For therapy of chemokine receptor related diseases and conditions such as rheumatoid arthritis, chronic obstructive pulmonary disease | ASTRAZENECA UK LIMITED (GB) | 2003-05-20 | — | — | US | disclosed |
| EP-1202984-B1 | DIPHENYL-PIPERIDINE DERIVATE | ASTRAZENECA UK LTD (GB) | 2003-03-05 | — | — | EP | disclosed |