Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 3/20 | 0.49 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.47 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.47 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.47 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.47 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.47 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.44 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.44 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.43 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.43 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.42 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.42 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.42 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.42 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.42 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.42 |
| ▸ | SCD5 | Q86SK9 | 3/20 | 0.40 |
| ▸ | SCD | O00767 | 2/20 | 0.40 |
| ▸ | PPID | Q08752 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3841906 | 0.87 | RIPK1 (0.51) | RIPK1CHRNB2CHRNB4CHRNA3CHRNA7 | |
| SCHEMBL8026883 | 0.83 | HSD11B1 (0.48) | RIPK1CHRNB2CHRNB4CHRNA3CHRNA7 | |
| SCHEMBL21312423 | 0.76 | RIPK1 (0.65) | RIPK1CHRNB2CHRNB4CHRNA3CHRNA7 | |
| SCHEMBL3056606 | 0.76 | RIPK1 (0.65) | RIPK1CHRNB2CHRNB4CHRNA3CHRNA7 | |
| SCHEMBL6763836 | 0.74 | GAA (0.45) | RIPK1HSD11B1 | |
| SCHEMBL1853141 | 0.71 | RIPK1 (0.69) | RIPK1CHRNB2CHRNB4CHRNA3CHRNA7 | |
| SCHEMBL1847627 | 0.71 | RIPK1 (0.69) | RIPK1CHRNB2CHRNB4CHRNA3CHRNA7 | |
| SCHEMBL17558248 | 0.71 | RIPK1 (0.69) | RIPK1CHRNB2CHRNB4CHRNA3CHRNA7 | |
| SCHEMBL19917196 | 0.71 | HSD11B1 (0.59) | RIPK1EPHX2HSD11B1HSP90AA1HSP90AB1 | |
| SCHEMBL3062584 | 0.70 | RIPK1 (0.67) | RIPK1CHRNB2CHRNB4CHRNA3CHRNA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1023265-B1 | AZETIDINONE DERIVATIVES FOR THE TREATMENT OF HCMV INFECTIONS | BOEHRINGER INGELHEIM CA LTD (CA) | 2003-01-15 | — | — | EP | disclosed |
| US-6211170-B1 | Azetidinone derivatives for the treatment of HCMV infections | BOEHRINGER INGELHEIM (CANADA) LTD. (CA) | 2001-04-03 | — | — | US | disclosed |
| EP-1023265-A1 | AZETIDINONE DERIVATIVES FOR THE TREATMENT OF HCMV INFECTIONS | BOEHRINGER INGELHEIM (CANADA) LTD. (CA) | 2000-08-02 | — | — | EP | disclosed |
| WO-1999018073-A1 | AZETIDINONE DERIVATIVES FOR THE TREATMENT OF HCMV INFECTIONS | BOEHRINGER INGELHEIM (CANADA) LTD. (CA) | 1999-04-15 | — | — | WO | disclosed |