Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGDS | O60760 | 1/20 | 0.67 |
| ▸ | BRAF | P15056 | 6/20 | 0.55 |
| ▸ | EGFR | P00533 | 5/20 | 0.55 |
| ▸ | KIT | P10721 | 13/20 | 0.54 |
| ▸ | CSF1R | P07333 | 12/20 | 0.54 |
| ▸ | DDR2 | Q16832 | 3/20 | 0.51 |
| ▸ | ABL1 | P00519 | 2/20 | 0.51 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.51 |
| ▸ | LCK | P06239 | 2/20 | 0.51 |
| ▸ | FYN | P06241 | 2/20 | 0.51 |
| ▸ | LYN | P07948 | 2/20 | 0.51 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.51 |
| ▸ | FGR | P09769 | 2/20 | 0.51 |
| ▸ | BCR | P11274 | 2/20 | 0.51 |
| ▸ | SRC | P12931 | 2/20 | 0.51 |
| ▸ | NQO2 | P16083 | 2/20 | 0.51 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.51 |
| ▸ | EPHA8 | P29322 | 2/20 | 0.51 |
| ▸ | ABL2 | P42684 | 2/20 | 0.51 |
| ▸ | FRK | P42685 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7677867 | 0.91 | HPGDS (0.66) | HPGDSBRAFEGFRKITCSF1R | |
| SCHEMBL6780729 | 0.88 | HPGDS (0.67) | HPGDSBRAFEGFRKITCSF1R | |
| SCHEMBL6973506 | 0.88 | HPGDS (0.64) | HPGDSBRAFEGFRKITCSF1R | |
| SCHEMBL6782706 | 0.87 | HPGDS (0.75) | HPGDSBRAFEGFRKITCSF1R | |
| SCHEMBL7681667 | 0.86 | HPGDS (0.63) | HPGDSBRAFEGFRKITCSF1R | |
| SCHEMBL6979954 | 0.86 | HPGDS (0.61) | HPGDSBRAFEGFRKITCSF1R | |
| SCHEMBL31721202 | 0.84 | HPGDS (0.69) | HPGDSBRAFEGFRKITCSF1R | |
| SCHEMBL6978632 | 0.84 | BRAF (0.70) | HPGDSBRAFEGFRKITCSF1R | |
| SCHEMBL6966564 | 0.83 | HPGDS (0.65) | HPGDSBRAFKITCSF1R | |
| SCHEMBL7606215 | 0.83 | HPGDS (0.60) | HPGDSBRAFEGFRKITCSF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1115707-B1 | BENZAMIDE DERIVATIVES AND THER USE AS CYTOKINE INHIBITORS | ASTRAZENECA AB (SE) | 2003-11-12 | — | — | EP | disclosed |
| US-6455520-B1 | TUMOR NECROSIS FACTOR AND INTERLEUKIN INHIBITORS; ANTIINFLAMMATORY AGENTS, ANTIALLERGENS; BONE DISORDERS | ASTRA ZENECA AB (SE) | 2002-09-24 | — | — | US | disclosed |
| EP-1115707-A1 | BENZAMIDE DERIVATIVES AND THER USE AS CYTOKINE INHIBITORS | AstraZeneca AB (SE) | 2001-07-18 | — | — | EP | disclosed |
| WO-2000018738-A1 | BENZAMIDE DERIVATIVES AND THEIR USE AS CYTOKINE INHIBITORS | ASTRAZENECA AB (SE) | 2000-04-06 | — | — | WO | disclosed |