Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGDS | O60760 | 1/20 | 0.61 |
| ▸ | MAPK14 | Q16539 | 9/20 | 0.51 |
| ▸ | BRAF | P15056 | 2/20 | 0.50 |
| ▸ | EGFR | P00533 | 1/20 | 0.50 |
| ▸ | CSF1R | P07333 | 6/20 | 0.48 |
| ▸ | KIT | P10721 | 6/20 | 0.48 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.47 |
| ▸ | SMO | Q99835 | 1/20 | 0.47 |
| ▸ | DDR2 | Q16832 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7835224 | 0.90 | LMNA (0.50) | HPGDSMAPK14BRAFEGFRCSF1R | |
| SCHEMBL6968243 | 0.88 | MAPK14 (0.61) | HPGDSMAPK14BRAF | |
| SCHEMBL6782251 | 0.87 | MAPK14 (0.66) | HPGDSMAPK14BRAFCSF1RKIT | |
| SCHEMBL6976773 | 0.86 | HPGDS (0.67) | HPGDSMAPK14BRAFEGFRCSF1R | |
| SCHEMBL6980722 | 0.85 | MAPK14 (0.65) | HPGDSMAPK14BRAF | |
| SCHEMBL27581172 | 0.84 | MAPK14 (0.58) | HPGDSMAPK14BRAFEGFRCSF1R | |
| SCHEMBL2972329 | 0.83 | MAPK14 (0.61) | HPGDSMAPK14BRAFCSF1RKIT | |
| SCHEMBL7677867 | 0.83 | HPGDS (0.66) | HPGDSMAPK14BRAFEGFRCSF1R | |
| SCHEMBL7779426 | 0.82 | MAPK14 (0.58) | HPGDSMAPK14BRAFSMO | |
| SCHEMBL4831705 | 0.82 | HPGDS (0.56) | HPGDSMAPK14BRAFCSF1RKIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1115707-B1 | BENZAMIDE DERIVATIVES AND THER USE AS CYTOKINE INHIBITORS | ASTRAZENECA AB (SE) | 2003-11-12 | — | — | EP | disclosed |
| US-6455520-B1 | TUMOR NECROSIS FACTOR AND INTERLEUKIN INHIBITORS; ANTIINFLAMMATORY AGENTS, ANTIALLERGENS; BONE DISORDERS | ASTRA ZENECA AB (SE) | 2002-09-24 | — | — | US | disclosed |
| EP-1115707-A1 | BENZAMIDE DERIVATIVES AND THER USE AS CYTOKINE INHIBITORS | AstraZeneca AB (SE) | 2001-07-18 | — | — | EP | disclosed |
| WO-2000018738-A1 | BENZAMIDE DERIVATIVES AND THEIR USE AS CYTOKINE INHIBITORS | ASTRAZENECA AB (SE) | 2000-04-06 | — | — | WO | disclosed |