Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRL1 | P41146 | 6/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | JAK1 | P23458 | 1/20 | 0.41 |
| ▸ | BCHE | P06276 | 1/20 | 0.41 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
| ▸ | BACE1 | P56817 | 1/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.40 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.39 |
| ▸ | FAAH | O00519 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.39 |
| ▸ | TACR1 | P25103 | 3/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6970037 | 0.99 | OPRL1 (0.47) | OPRL1POLBGAAHDAC1HDAC7 | |
| SCHEMBL6976284 | 0.88 | OPRL1 (0.48) | OPRL1POLBGAAHDAC1ALDH1A1 | |
| SCHEMBL6975032 | 0.87 | OPRD1 (0.42) | OPRL1POLBHDAC1HDAC7KDM4E | |
| Hydrochloric Acid SCHEMBL6980309 | 0.86 | OPRD1 (0.41) | OPRL1POLBHDAC1HDAC7KDM4E | |
| SCHEMBL6976116 | 0.86 | CCR3 (0.46) | OPRL1POLBALDH1A1OPRM1SIGMAR1 | |
| SCHEMBL6970497 | 0.85 | LMNA (0.47) | OPRL1POLBHDAC1KDM4EALDH1A1 | |
| Hydrochloric Acid SCHEMBL6971416 | 0.85 | CCR3 (0.45) | OPRL1POLBALDH1A1OPRM1SIGMAR1 | |
| Hydrochloric Acid SCHEMBL6981064 | 0.84 | POLB (0.46) | OPRL1POLBHDAC1KDM4EALDH1A1 | |
| SCHEMBL6973419 | 0.82 | OPRL1 (0.53) | OPRL1POLBKDM4EFAAHSIGMAR1 | |
| SCHEMBL6972025 | 0.82 | ALDH1A1 (0.42) | OPRL1ALDH1A1SIGMAR1DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6566376-B1 | For therapy of chemokine receptor related diseases and conditions such as rheumatoid arthritis, chronic obstructive pulmonary disease | ASTRAZENECA UK LIMITED (GB) | 2003-05-20 | — | — | US | claimed |
| EP-1202984-B1 | DIPHENYL-PIPERIDINE DERIVATE | ASTRAZENECA UK LTD (GB) | 2003-03-05 | — | — | EP | claimed |
| US-6566376-B1 | For therapy of chemokine receptor related diseases and conditions such as rheumatoid arthritis, chronic obstructive pulmonary disease | ASTRAZENECA UK LIMITED (GB) | 2003-05-20 | — | — | US | disclosed |
| EP-1202984-B1 | DIPHENYL-PIPERIDINE DERIVATE | ASTRAZENECA UK LTD (GB) | 2003-03-05 | — | — | EP | disclosed |