Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | PDK2 | Q15119 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 4/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | MPI | P34949 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | APAF1 | O14727 | 1/20 | 0.37 |
| ▸ | TDP2 | O95551 | 1/20 | 0.37 |
| ▸ | NSD2 | O96028 | 1/20 | 0.37 |
| ▸ | ABL1 | P00519 | 1/20 | 0.37 |
| ▸ | GALK1 | P51570 | 1/20 | 0.37 |
| ▸ | BLM | P54132 | 1/20 | 0.37 |
| ▸ | PPP1CA | P62136 | 1/20 | 0.37 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.37 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.37 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7815888 | 0.93 | GAA (0.42) | GAAALDH1A1LMNAPDK2MAPT | |
| SCHEMBL6981621 | 0.83 | APEX1 (0.42) | ALDH1A1LMNAMAPTHTTMAPK1 | |
| SCHEMBL4902934 | 0.77 | GAA (0.43) | GAAALDH1A1LMNAL3MBTL1CTDSP1 | |
| SCHEMBL6978137 | 0.74 | OPRM1 (0.43) | GAAALDH1A1LMNAMAPTHPGD | |
| SCHEMBL6979007 | 0.73 | OPRM1 (0.41) | ALDH1A1LMNAMAPTHPGDHTT | |
| SCHEMBL24981178 | 0.73 | ALDH1A1 (0.44) | GAAALDH1A1LMNAPDK2MAPT | |
| SCHEMBL17051306 | 0.73 | APEX1 (0.47) | GAAALDH1A1LMNAPDK2MAPT | |
| SCHEMBL6975621 | 0.72 | APP (0.38) | GAAALDH1A1LMNAMAPTHPGD | |
| SCHEMBL11110321 | 0.72 | ALDH1A1 (0.47) | GAAALDH1A1LMNAPDK2MAPT | |
| SCHEMBL180341 | 0.71 | CTDSP1 (0.47) | GAAALDH1A1LMNAHPGDKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1098893-B1 | CYCLIC COMPOUNDS USEFUL IN THE TREATMENT OF DYSLIPIDEMIA, ATHEROSCLEROSIS AND DIABETES, PHARMACEUTICAL COMPOSITIONS AND PREPARATION PROCESS | MERCK PATENT GMBH (DE) | 2003-03-26 | — | — | EP | disclosed |