Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 10/20 | 0.43 |
| ▸ | BCHE | P06276 | 6/20 | 0.43 |
| ▸ | NAMPT | P43490 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | LTA4H | P09960 | 1/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.38 |
| ▸ | PAK4 | O96013 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6977152 | 1.00 | ACHE (0.43) | ACHEBCHENAMPTHDAC1LTA4H | |
| SCHEMBL6982529 | 0.94 | ROCK2 (0.43) | HDAC1ROCK2PAK4 | |
| SCHEMBL6982535 | 0.94 | ROCK2 (0.43) | HDAC1ROCK2PAK4 | |
| SCHEMBL7233622 | 0.92 | ACHE (0.44) | ACHEBCHENAMPTHDAC1LTA4H | |
| SCHEMBL7233617 | 0.92 | ACHE (0.44) | ACHEBCHENAMPTHDAC1LTA4H | |
| SCHEMBL6979863 | 0.90 | ACHE (0.44) | ACHEBCHENAMPTHDAC1LTA4H | |
| SCHEMBL6979865 | 0.90 | ACHE (0.44) | ACHEBCHENAMPTHDAC1LTA4H | |
| SCHEMBL6980866 | 0.89 | SIGMAR1 (0.45) | ACHEBCHENAMPT | |
| SCHEMBL6980870 | 0.89 | SIGMAR1 (0.45) | ACHEBCHENAMPT | |
| SCHEMBL8186890 | 0.89 | MEN1 (0.46) | ACHEBCHENAMPTHDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1071665-B1 | SUBSTITUTED INDOLINONES HAVING AN INHIBITING EFFECT ON KINASES AND CYCLINE/CDK COMPLEXES | BOEHRINGER INGELHEIM PHARMA (DE) | 2003-10-01 | — | — | EP | disclosed |
| EP-1071665-A1 | SUBSTITUTED INDOLINONES HAVING AN INHIBITING EFFECT ON KINASES AND CYCLINE/CDK COMPLEXES | Boehringer Ingelheim Pharma KG (DE) | 2001-01-31 | — | — | EP | disclosed |
| US-6169106-B1 | ANTITUMOUR AGENTS | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2001-01-02 | — | — | US | disclosed |
| WO-1999052869-A1 | SUBSTITUTED INDOLINONES HAVING AN INHIBITING EFFECT ON KINASES AND CYCLINE/CDK COMPLEXES | BOEHRINGER INGELHEIM PHARMA KG (DE) | 1999-10-21 | — | — | WO | disclosed |