Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 10/20 | 0.45 |
| ▸ | TMEM97 | Q5BJF2 | 9/20 | 0.45 |
| ▸ | ACHE | P22303 | 4/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.41 |
| ▸ | BCHE | P06276 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | NAMPT | P43490 | 1/20 | 0.40 |
| ▸ | GRK5 | P34947 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6980866 | 1.00 | SIGMAR1 (0.45) | SIGMAR1TMEM97ACHEOPRM1BCHE | |
| SCHEMBL6985634 | 0.94 | ROCK2 (0.42) | SIGMAR1TMEM97NAMPTGRK5 | |
| SCHEMBL6985636 | 0.94 | ROCK2 (0.42) | SIGMAR1TMEM97NAMPTGRK5 | |
| SCHEMBL7227469 | 0.92 | TMEM97 (0.44) | SIGMAR1TMEM97ACHEOPRM1BCHE | |
| SCHEMBL7227472 | 0.92 | TMEM97 (0.44) | SIGMAR1TMEM97ACHEOPRM1BCHE | |
| SCHEMBL6977152 | 0.89 | ACHE (0.43) | ACHEBCHENAMPT | |
| SCHEMBL6977153 | 0.89 | ACHE (0.43) | ACHEBCHENAMPT | |
| SCHEMBL6979739 | 0.89 | L3MBTL1 (0.45) | KDM4EGAAKMT2ANAMPTGRK5 | |
| SCHEMBL6979734 | 0.89 | L3MBTL1 (0.45) | KDM4EGAAKMT2ANAMPTGRK5 | |
| SCHEMBL436992 | 0.89 | TMEM97 (0.42) | SIGMAR1TMEM97OPRM1KDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1071665-B1 | SUBSTITUTED INDOLINONES HAVING AN INHIBITING EFFECT ON KINASES AND CYCLINE/CDK COMPLEXES | BOEHRINGER INGELHEIM PHARMA (DE) | 2003-10-01 | — | — | EP | disclosed |
| EP-1071665-A1 | SUBSTITUTED INDOLINONES HAVING AN INHIBITING EFFECT ON KINASES AND CYCLINE/CDK COMPLEXES | Boehringer Ingelheim Pharma KG (DE) | 2001-01-31 | — | — | EP | disclosed |
| US-6169106-B1 | ANTITUMOUR AGENTS | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2001-01-02 | — | — | US | disclosed |
| WO-1999052869-A1 | SUBSTITUTED INDOLINONES HAVING AN INHIBITING EFFECT ON KINASES AND CYCLINE/CDK COMPLEXES | BOEHRINGER INGELHEIM PHARMA KG (DE) | 1999-10-21 | — | — | WO | disclosed |